{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:06:06Z","timestamp":1787972766643,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acquired dermal macular hyperpigmentation (<jats:styled-content style=\"fixed-case\">ADMH<\/jats:styled-content>) is an umbrella term including lichen planus pigmentosus, erythema dyschromicum perstans and pigmented contact\/cosmetic dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish contact sensitization to hair colours as an aetiological factor for <jats:styled-content style=\"fixed-case\">ADMH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Detailed clinical examination, skin biopsies, and patch and photo\u2010patch testing with Indian standard series and patient's own cosmetic products were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine (36.1%) patients were found to demonstrate a positive patch\/photo\u2010patch test with 35\/39 reacting to their own products (all were hair colours) and 16\/39 reacting to antigens from commercial series (commonly paraphenylenediamine). Fourteen patients developed delayed hyperpigmentation on positive patch\u2010test sites at 1 month.<\/jats:p><jats:p>Higher mean age, symptomatic pigmentation (pruritus, burning and photosensitivity), hair margins involvement (outer surface, helix and lobule of ear; temples and preauricular area), ill\u2010defined lesions, epidermal atrophy and epidermal melanization extending &gt;3 layers were significantly common in patch\u2010test\u2010positive patients. Well\u2010defined lesions, perioral involvement and associated lichen planus were clinical pointers towards patch\u2010test negativity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Index study exemplifies that patch\u2010test results have distinct clinical and histopathological correlates in <jats:styled-content style=\"fixed-case\">ADMH<\/jats:styled-content>. Hair dye contact sensitization appears to be an important aetiological factor in about one\u2010third patients presenting with <jats:styled-content style=\"fixed-case\">ADMH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15576","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T01:50:02Z","timestamp":1552960202000},"page":"1349-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Contact sensitization to hair colours in acquired dermal macular hyperpigmentation: results from a patch and photo\u2010patch test study of 108 patients"],"prefix":"10.1111","volume":"33","author":[{"given":"A.","family":"Bishnoi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh 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