{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:32:26Z","timestamp":1790386346493,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Management of moderate\u2010to\u2010severe atopic dermatitis (AD) frequently requires treatment with systemic therapies. Dupilumab is the first biological agent approved for treatment of moderate\u2010to\u2010severe AD. Although promising results have appeared in clinical trials, real\u2010life data on efficacy and safety are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess effectiveness and safety of treatment with dupilumab in the real\u2010life clinical setting at a Danish tertiary referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with AD treated with dupilumab from October 2017 to October 2018 at Bispebjerg Hospital, Denmark, were included in the study. Patients were evaluated three times: at treatment initiation and at 1 and 3 months after first dupilumab injection. At each visit, disease activity was assessed by severity score (Eczema Area and Severity Index, EASI), patient\u2010reported outcomes (Dermatology Life Quality Index, DLQI, pruritus and sleep score) and serological markers [immunoglobulin (Ig)E, eosinophil count and lactate dehydrogenase (LDH)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 43 patients were included in the study. The mean reduction in EASI score from baseline was 19.6 points (72.4%) at 1\u2010month and 22.6 points (76.7%) at 3\u2010month follow\u2010up. EASI, DLQI, pruritus score, sleep score, IgE and LDH were all statistically significantly reduced between baseline and 1\u2010 and 3\u2010month follow\u2010up. Mean reductions in EASI score and LDH at 3\u2010month follow\u2010up were significantly correlated (<jats:italic>P<\/jats:italic> = 0.003). One patient (2.3%) discontinued treatment due to side\u2010effects, and seven patients (18.4%) developed conjunctivitis during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The effectiveness and safety of dupilumab treatment in a real\u2010life clinical setting are comparable to that of phase 3 clinical trials. LDH is suggested as a potential serological marker predictive of treatment response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15609","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T23:59:56Z","timestamp":1554767996000},"page":"1562-1568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Treatment of atopic dermatitis with dupilumab: experience from a tertiary referral centre"],"prefix":"10.1111","volume":"33","author":[{"given":"C.M.","family":"Olesen","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010venereology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010venereology Bispebjerg Hospital University of Copenhagen Copenhagen 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