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However, the diagnosis and definite significance of infantile <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> remains a debated issue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyse the phenotypes of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in infancy, to establish diagnostic criteria and to estimate the prevalence of this condition in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a multicentric study, in which 12 locations were chosen from different metropolitan areas of China. Following careful and complete history\u2010taking and skin examination, the definite diagnosis of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was made and the severity based on the <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content> index was determined by local experienced dermatologists. Based on the detailed phenotyping, the major and representative clinical features of infantile <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> were selected to establish the diagnostic criteria and evaluate their diagnostic efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5967 infants were included in this study. The overall point prevalence of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was 30.48%. The infantile <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> developed as early as at the second month of life, and its incidence peaked in the third month of life at 40.81%. The proportion of mild, moderate and severe <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was 67.40%, 30.57% and 2.03%, respectively. The most commonly seen manifestations in the infantile <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> were facial dermatitis (72.07%), xerosis (42.72%) and scalp dermatitis (27.93%). We established the novel diagnostic criteria of infants, which included: (i) onset after 2 weeks of birth; (ii) pruritus and\/or irritability and sleeplessness comparable with lesions; and (iii) all two items above with one of the following items can reach a diagnosis of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>: (i) eczematous lesions distributed on cheeks and\/or scalp and\/or extensor limbs, and (ii) eczematous lesions on any other parts of body accompanied by xerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In China, the prevalence of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in infancy is 30.48% according to clinical diagnosis of dermatologists. The novel Chinese diagnostic criteria for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in infants show a higher sensitivity and comparable specificity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15618","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T05:24:09Z","timestamp":1555392249000},"page":"1569-1576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Phenotypic analysis of atopic dermatitis in children aged 1\u201312 months: elaboration of novel diagnostic criteria for infants in China and estimation of prevalence"],"prefix":"10.1111","volume":"33","author":[{"given":"Y.","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Dermatology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Institute of Dermatology Shanghai Jiaotong University School of Medicine Shanghai 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