{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:06:26Z","timestamp":1788404786051,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmune processes are considered to play a major role in the pathogenesis of chronic spontaneous urticaria (CSU). Very recently, interleukin 24 (IL\u201024) has been identified as an immunoglobulin E (IgE) autoantigen in CSU. Some studies revealed that notably autologous serum skin test (ASST)\u2010positive CSU patients may benefit from autohemotherapy; however, the mechanisms of action remain unknown. We aimed to investigate the immunological effects of autologous serum injections in ASST\u2010positive CSU patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010six ASST\u2010positive CSU patients were treated with weekly intramuscular autologous serum injections for 8 weeks and followed up for 12 weeks. Urticaria activity score (UAS7) and Dermatology Life Quality Index (DLQI) were assessed. The ASST was done at baseline, week 9 and week 21. Serum samples (baseline, weeks 9, 13 and\/or 21) were analysed for the levels of IgE\u2010anti\u2010IL\u201024 and immunoglobulin G (IgG)\u2010anti\u2010IL\u201024 via ELISA and their ability to release histamine in basophils [basophil histamine release assay (BHRA)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Autologous serum therapy resulted in a substantial improvement in disease activity and quality of life after 8 and 20 weeks. Twenty\u2010eight percent and 34% of patients turned ASST\u2010negative in weeks 9 and 21, respectively, but there was no link between their response to treatment and changes of ASST results. Also, no significant or relevant changes in BHRA were observed. In contrast, autologous serum therapy significantly decreased IgE\u2010anti\u2010IL\u201024 serum levels, but not IgG\u2010anti\u2010IL\u201024 serum levels, in responders but not in non\u2010responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that the immunological effects of autologous serum therapy include a reduction in IgE\u2010anti\u2010IL24 autoantibodies, which may contribute to the pathogenesis of CSU.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15640","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T08:31:48Z","timestamp":1556267508000},"page":"1747-1754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Immunological effects and potential mechanisms of action of autologous serum therapy in chronic spontaneous urticaria"],"prefix":"10.1111","volume":"33","author":[{"given":"L.","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Buttgereit","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Stahl Skov","sequence":"additional","affiliation":[{"name":"Odense Research Center of Anaphylaxis Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Schmetzer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Scheffel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kocat\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okmeydani Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Zawar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Godavari Foundation Medical College and Research Center Nashik India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Magerl","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin 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