{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:08:37Z","timestamp":1787015317013,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Comedogenesis is defined as the process of the development of a new comedo, which is of great importance for the understanding of acne.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the formation and evolution of acne lesions from clinically unaffected skin of patients with mild\u2013moderate acne to characterize the morphological changes and natural resolution by means of\n                      <jats:italic>in vivo<\/jats:italic>\n                      reflectance confocal microscopy (RCM) and dynamic optical coherence tomography (D\u2010OCT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten patients with mild\u2013moderate acne, not assuming any topical or systemic therapy, comprised between 12 and 30 years of age, were recruited. A target area of 4 \u00d7 4 mm of the face, without acne lesions at baseline, was selected. A set of standardized clinical pictures, RCM and D\u2010OCT images were acquired weekly for 6 weeks and evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy full sets of clinical, RCM and D\u2010OCT images were analysed. The appearance of acne lesion is preceded by an increase of large bright follicles in the area corresponding to infundibular keratinization, followed by increment of inflammation parameter, such as increased of small bright cells upon RCM and vascular network upon D\u2010OCT, which return to normal after the resolution of acute inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acne skin dynamics is complex and seems characterized by the early increase in the number of dysmorphic pilosebaceous units and the hyperkeratinization of the acroinfundibulum of the pilosebaceous duct prior to the occurrence of inflammatory events around the follicle. The processes of hyperkeratinization and inflammatory phenomena may generate a pathologic vicious cycle, which characterizes acne through progressive worsening and a self\u2010sustainment mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.15641","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T04:30:24Z","timestamp":1556253024000},"page":"1768-1774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The evolution of healthy skin to acne lesions: a longitudinal,\n                    <i>in vivo<\/i>\n                    evaluation with reflectance confocal microscopy and optical coherence tomography"],"prefix":"10.1111","volume":"33","author":[{"given":"M.","family":"Manfredini","sequence":"first","affiliation":[{"name":"Department of Surgical, Medical, Dental &amp; Morphological Sciences with Interest Transplant Oncological &amp; Regenerative Medicine Dermatology Unit University of Modena &amp; Reggio Emilia Modena Italy"},{"name":"Department of Medical Sciences Section of Dermatology University of Ferrara Ferrara Italy"},{"name":"Dermatology Unit Nuovo Ospedale Civile di Sassuolo Sassuolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bettoli","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Section of Dermatology University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sacripanti","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Dental &amp; Morphological Sciences with Interest Transplant Oncological &amp; Regenerative Medicine Dermatology Unit University of Modena &amp; Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Farnetani","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Dental &amp; Morphological Sciences with Interest Transplant Oncological &amp; Regenerative Medicine Dermatology Unit University of Modena &amp; Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bigi","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Dental &amp; Morphological Sciences with Interest Transplant Oncological &amp; Regenerative Medicine Dermatology Unit University of Modena &amp; Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Puviani","sequence":"additional","affiliation":[{"name":"Dermatology Unit Nuovo Ospedale Civile di Sassuolo Sassuolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Corazza","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Section of Dermatology University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Dental &amp; Morphological Sciences with Interest Transplant Oncological &amp; Regenerative Medicine Dermatology Unit University of Modena &amp; Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1702493"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0558-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2847"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000382031"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-97234-8_8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.12788\/J.SDER.2018.024"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12917"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067825"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01459"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00595286"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12730"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14369"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13910"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12298"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12255"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22339"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546639809160698"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444706"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14508"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12833"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14463"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.15641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.15641","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:56:06Z","timestamp":1694051766000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,8]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/jdv.15641"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15641","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,8]]},"assertion":[{"value":"2018-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}