{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:32:07Z","timestamp":1779147127369,"version":"3.51.4"},"reference-count":68,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There have been conflicting results about the association between Beh\u00e7et's disease and smoking. Smoking has been reported to be a protective factor for Beh\u00e7et's disease, whereas smoking may have a role in triggering Beh\u00e7et's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate the incidence of Beh\u00e7et's disease in Korea according to smoking status using nationwide population data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed clinical data from individuals 20\u00a0years of age and older who received a health examination arranged by the Korean national insurance programme between 2009 and 2012. The incidence of Beh\u00e7et's disease was analysed according to smoking status reported by individuals during their health examination. Newly diagnosed cases of Beh\u00e7et's disease were identified using claims data from baseline to the date of diagnosis or until 31 December 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risk of Beh\u00e7et's disease was lower in current smokers compared with never\u2010smokers regardless of the amount and duration of smoking. The decreased risk of Beh\u00e7et's disease in current smoker persisted after adjusting for age, sex, regular exercise, drinking status, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, diabetes mellitus, hypertension, and dyslipidaemia, history of stroke and\/or history of ischaemic heart diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Genetic susceptibility or family history of Beh\u00e7et's disease was not considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study found a decreased incidence of Beh\u00e7et's disease in current smokers compared with never\u2010smokers. Further investigation of the pathophysiology responsible for the negative association between smoking and Beh\u00e7et's disease is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15708","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T19:30:07Z","timestamp":1558639807000},"page":"2114-2122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association between smoking and Beh\u00e7et's disease: a nationwide population\u2010based study in Korea"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8642-2479","authenticated-orcid":false,"given":"Y.B.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.S.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.D.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.G.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.035"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100033552"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14601"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.106"},{"key":"e_1_2_6_7_1","first-page":"S27","article-title":"The role of infectious agents in the pathogenesis, clinical manifestations and treatment strategies in Behcet's disease","volume":"25","author":"Mumcu G","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-306-48382-3_35"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.996"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2018.1493065"},{"key":"e_1_2_6_11_1","first-page":"S14","article-title":"The impact of smoking on clinical features of Behcet's disease patients with glutathione S\u2010transferase polymorphisms","volume":"30","author":"Ozer HT","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-006-0541-z"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-306-48382-3_64"},{"key":"e_1_2_6_14_1","first-page":"S77","article-title":"The therapeutic effect of cigarette smoking on oral\/genital aphthosis and other manifestations of Behcet's disease","volume":"19","author":"Rizvi SW","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670070020"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32801127c8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep401"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670200090"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700492"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012143432418"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.177"},{"key":"e_1_2_6_22_1","first-page":"546","article-title":"A case of neuro\u2010Behcet's disease with transient cerebral ischemia evoked by smoking","volume":"39","author":"Tanaka T","year":"1999","journal-title":"Rinsho Shinkeigaku (Clin Neurol)"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1990.tb00819.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02113.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb14818.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04700.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03860.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.12.1580"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-018-1867-z"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16261"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16561"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.04.006"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.041"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.001"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018126"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930500285758"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20049"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111609"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2010.19.1.46092"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.3.397"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12092.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(01)00112-8"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90296-3"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-018-9021-8"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14886"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03645.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.15135.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02390.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.01266.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy230"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004953"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00074"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-7243(200005\/06)15:3<165::AID-BIO582>3.0.CO;2-X"},{"key":"e_1_2_6_54_1","first-page":"414","article-title":"Effects of the serum obtained from smoke inhalation injury rats on PMN adhesion and transmigration in vitro","volume":"14","author":"Luo Q","year":"1998","journal-title":"Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1977.tb00126.x"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527314666150325235608"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31819e98f"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.11.030"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.12.003"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2008.073577"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01339"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013070"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.11.053"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890430023004"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020487"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090212"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200206096"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12325606"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018626"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.15708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.15708","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:26:42Z","timestamp":1694240802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":68,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/jdv.15708"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15708","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"2019-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}