{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:19:01Z","timestamp":1791231541644,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The differential diagnosis of nipple and areola complex (\n                    <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content>\n                    ) lesions encompasses a large spectrum of conditions from benign tumours to inflammatory diseases that could be challenging to recognize on clinical ground. While melanoma (\n                    <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                    ) of the\n                    <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content>\n                    is exceedingly rare, benign lesions are more frequent but could be difficult to distinguish from\n                    <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                    . Besides\n                    <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                    , other malignant tumours can affect this area and in particular Paget's disease (\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    ). For clinically doubtful lesions, biopsy is required, with possible functional and aesthetic consequences in this sensitive area. Dermoscopy and reflectance confocal microscopy (\n                    <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                    ) are widely used techniques for the diagnosis of many skin lesions, but their use for\n                    <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content>\n                    lesions is not well established. The objective of this study was to evaluate current literature on these imaging techniques for\n                    <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content>\n                    lesions. We searched in Medline, PubMed and Cochrane database all studies up to November 2018 dealing with dermoscopy,\n                    <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                    and this special site. We found that the most described malignant tumour was\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    and that only two primary\n                    <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                    s of the\n                    <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content>\n                    have been reported with these imaging techniques. Although there are few data on diagnostic accuracy of non\u2010invasive imaging techniques for\n                    <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content>\n                    lesions, it seems that dermoscopy and\n                    <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                    can add relevant information to be integrated with clinical examination for the diagnosis of\n                    <jats:styled-content style=\"fixed-case\">NAC<\/jats:styled-content>\n                    lesions and in particular for the differential diagnosis of\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    and eczema.\n                  <\/jats:p>","DOI":"10.1111\/jdv.15727","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T07:36:07Z","timestamp":1559720167000},"page":"1837-1846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Nipple and areola lesions: review of dermoscopy and reflectance confocal microscopy features"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-0659","authenticated-orcid":false,"given":"E.","family":"Cinotti","sequence":"first","affiliation":[{"name":"Dermatology Section Department of Medical, Surgical and Neurological Science S. 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Maria alle Scotte Hospital University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Habougit","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of St\u2010Etienne Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Manganoni","sequence":"additional","affiliation":[{"name":"Department of Dermatology Azienda Ospedaliera Spedali Civili di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Venturini","sequence":"additional","affiliation":[{"name":"Department of Dermatology Azienda Ospedaliera Spedali Civili di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Perrot","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of St\u2010Etienne Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Dermatology Section Department of Medical, Surgical and Neurological Science S. 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