{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:42:27Z","timestamp":1791852147764,"version":"4.3.4"},"reference-count":67,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>New or important issues in this updated version of the 2013 European guideline on the management of lymphogranuloma venereum (LGV):<\/jats:p><\/jats:sec><jats:sec><jats:title>Epidemiology<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Lymphogranuloma venereum continues to be endemic among European men who have sex with men (MSM) since 2003.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Lymphogranuloma venereum infections in heterosexuals are extremely rare in Europe, and there is no evidence of transmission of LGV in the European heterosexual population.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Aetiology and transmission<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p><jats:italic>Chlamydia trachomatis<\/jats:italic> serovars\/genovars L2b and L2 are the causative strains in the majority of cases in Europe.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical features<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Among MSM, about 25% of the anorectal LGV infections are asymptomatic.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Genital infections among MSM are rare; the ratio of genital vs. anorectal LGV infections is 1 in 15.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Diagnosis<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>To diagnose LGV, a sample tested <jats:italic>C.\u00a0trachomatis<\/jats:italic> positive with a commercial nucleic acid amplification test (NAAT) platform should be confirmed with an LGV discriminatory NAAT.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Treatment<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Doxycycline 100\u00a0mg twice a day orally for 21\u00a0days is the recommended treatment for LGV.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>This same treatment is recommended also in asymptomatic patients and contacts of LGV patients. 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