{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:45:41Z","timestamp":1785545141189,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our suggested \u2018modern\u2019 concepts of \u2018neutrophilic dermatoses\u2019 (<jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>) and \u2018neutrophilic disease\u2019 were based on observations in adult patients and have not been studied in paediatric patients. Only a minority of <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> occurs in children, and little is known about age\u2010specific characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe age\u2010specific characteristics of <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> in children and to study whether our suggested \u2018modern\u2019 classification of <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> may be applied to children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective multicentre study in a French cohort of 27 paediatric patients diagnosed with pyoderma gangrenosum (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>) or Sweet's syndrome (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Demographics and distribution of typical\/atypical forms were similar in patients diagnosed with <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>. Atypical <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> were more frequent in infants (90%), when compared to young children (60%) and adolescents (33%). Neutrophilic disease was observed in 17\/27 patients and was most frequent in infants. Neutrophilic disease of the upper respiratory tract, as well as cardiac neutrophilic disease, was only observed in infants, whereas other locations were similarly found in infants, young children and adolescents. In infants and young children, <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> were associated with a large spectrum of general diseases, whereas in adolescents associations were limited to inflammatory bowel disease and Beh\u00e7et's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study describes the concept of <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> in paediatric patients and shows that they have some characteristics different from <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> occurring in adults. <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> occurring in infants can be associated with a large spectrum of general diseases. Occurrence of neutrophilic disease is frequent in children. Thus, <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content> occurring in young paediatric patients should incite clinicians to schedule complementary explorations in order to search for involvement of other organs and to rule out monogenetic autoinflammatory syndromes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15730","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T12:03:26Z","timestamp":1559736206000},"page":"2179-2187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Age\u2010specific characteristics of neutrophilic dermatoses and neutrophilic diseases in children"],"prefix":"10.1111","volume":"33","author":[{"given":"M.","family":"Bucchia","sequence":"first","affiliation":[{"name":"Centre Hospitalier Le Mans Service Urgences p\u00e9diatriques Le Mans France"},{"name":"Centre de r\u00e9f\u00e9rence des rhumatismes inflammatoires et maladies auto\u2010immunes 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