{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:33:39Z","timestamp":1766486019537,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Pure desmoplastic melanoma (pDM<\/jats:styled-content>) is an uncommon subtype of malignant melanoma with comparative high rates of local recurrence and low rates of sentinel lymph node positivity. The melanoma\u2010specific survival (MSS<\/jats:styled-content>) of pDM<\/jats:styled-content> compared to other melanoma subtypes is unclear, with conflicting reports and lack of multivariable analyses.<\/jats:p><\/jats:sec>Objectives<\/jats:title>We aimed to describe clinicopathological characteristics of a cohort of patients with pDM<\/jats:styled-content> and to compare the MSS<\/jats:styled-content> of pDM<\/jats:styled-content> with superficial spreading melanoma (SSM<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective cohort study was performed of all primary invasive cutaneous pDM<\/jats:styled-content> with known tumour location and thickness reviewed at a tertiary referral centre over 21\u00a0years.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 119 primary cutaneous invasive pDM<\/jats:styled-content>s from 3570 total invasive cutaneous melanomas were included. Compared to 2272 SSM<\/jats:styled-content>s, and due largely to their greater average thickness, patients with pDM<\/jats:styled-content> had worse MSS<\/jats:styled-content> (unadjusted hazard ratio, HR<\/jats:styled-content>, 2.56, 95% confidence interval, CI<\/jats:styled-content>, 1.56\u20134.22). After adjustment for clinicopathologic factors (including thickness, ulceration, mitotic rate, age and sex), there was evidence that patients with pDM<\/jats:styled-content> had an improved MSS<\/jats:styled-content> (adjusted HR<\/jats:styled-content>, 0.49; 95% CI<\/jats:styled-content>, 0.28\u20130.87). Median thickness of head and neck pDM<\/jats:styled-content> was greater than non\u2010head and neck pDM<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.001). There was reduced univariable MSS<\/jats:styled-content> in head and neck pDM<\/jats:styled-content> compared to the rest of the body.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Decreased univariable MSS<\/jats:styled-content> of patients with pDM<\/jats:styled-content> compared to SSM<\/jats:styled-content> was explained by the increased frequency of adverse clinicopathologic features at diagnosis, in particular the greater Breslow thickness of pDM<\/jats:styled-content>. After adjustment, patients with pDM<\/jats:styled-content> had half the chance of melanoma\u2010specific death compared to SSM<\/jats:styled-content>. Head and neck pDM<\/jats:styled-content> were thicker at diagnosis compared to the rest of the body, which may account for its poorer survival compared to the rest of the body.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15759","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T19:50:00Z","timestamp":1561492200000},"page":"1899-1906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Differences between pure desmoplastic melanoma and superficial spreading melanoma in terms of survival, distribution and other clinicopathologic features"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7988-7577","authenticated-orcid":false,"given":"M.D.","family":"Howard","sequence":"first","affiliation":[{"name":"Victorian Melanoma Service Alfred Hospital Melbourne Vic. Australia"},{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Vincent's Hospital Melbourne Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.A.","family":"McLean","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service Alfred Hospital Melbourne Vic. Australia"},{"name":"Department of Pathology Alfred Hospital Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.W.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service Alfred Hospital Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Pan","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service Alfred Hospital Melbourne Vic. 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