{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:02:24Z","timestamp":1777539744059,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["EFOP\u20103.6.3\u2010VEKOP\u201016\u20102017\u201000007"],"award-info":[{"award-number":["EFOP\u20103.6.3\u2010VEKOP\u201016\u20102017\u201000007"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The assessment of health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) in patients with pemphigus is now of increasing interest due to the availability of highly effective new therapies. Preference\u2010based <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL values or health utilities required for medical and financial decision\u2010making are not yet available directly from pemphigus patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To obtain health utility values for current health and hypothetical health states from the perspective of pemphigus patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional questionnaire survey was carried out with pemphigus patients. Disease severity was rated by Autoimmune Bullous Skin Disorder Intensity Score (<jats:styled-content style=\"fixed-case\">ABSIS<\/jats:styled-content>). Patients were asked to evaluate their current health as well as three common hypothetical pemphigus health states [uncontrolled pemphigus vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>), uncontrolled pemphigus foliaceus (<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>) and controlled <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>] by using composite time trade\u2010off (<jats:styled-content style=\"fixed-case\">cTTO<\/jats:styled-content>). Multiple regression was applied to explore determinants of utility values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Responses of 108 patients (64.8% women, mean age 57.4\u00a0years) were analysed. Mean <jats:styled-content style=\"fixed-case\">ABSIS<\/jats:styled-content> score was 11.6. The mean utility values for the hypothetical uncontrolled <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>, uncontrolled <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> and controlled <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> health states were 0.41, 0.52 and 0.66 with <jats:styled-content style=\"fixed-case\">cTTO<\/jats:styled-content>. The mean <jats:styled-content style=\"fixed-case\">cTTO<\/jats:styled-content> scores for current health were higher compared with the hypothetical health states (0.76; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Patients with higher <jats:styled-content style=\"fixed-case\">ABSIS<\/jats:styled-content>, worse pain intensity scores and those having a caregiver reported lower utility values for current health (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In pemphigus, <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL impairment expressed in utility values seems to be considerable, especially in comparison with other chronic dermatological conditions (e.g. psoriasis, atopic eczema, chronic hand eczema). These health utilities inform physicians, policymakers and funders about the overall extent of health loss in pemphigus and provide evidence to guide medical decisions and cost\u2010effectiveness analyses of treatment strategies. Future research is needed to evaluate the caregiver burden in pemphigus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15765","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T13:33:41Z","timestamp":1562074421000},"page":"2106-2113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Patient\u2010assigned health utility values for controlled and uncontrolled pemphigus vulgaris and foliaceus"],"prefix":"10.1111","volume":"33","author":[{"given":"K.","family":"Hajdu","sequence":"first","affiliation":[{"name":"Departments of Dermatology Faculty of Medicine University of Debrecen Debrecen Hungary"},{"name":"Department of Dermatological Allergology Faculty of Medicine University of Debrecen Debrecen 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