{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T09:16:51Z","timestamp":1694337411778},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Keratinocyte cancers (KC) are common and pose a significant financial burden globally. Ultraviolet radiation is a significant factor in their development, through mutagenesis promotion but also through local and systemic immunosuppression. Although systemic immunosuppression is well understood, cutaneous immunity has been more difficult to evaluate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study used a contact sensitizer, diphencyprone (DPCP), which elicits a contact hypersensitivity reaction in skin, to compare the degree of reactivity to DPCP in patients with a high KC burden versus those with a low KC burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was performed in immunocompetent patients aged 70\u00a0\u00b1\u00a05\u00a0years of age, comparing patients with a high KC burden (&gt;10 previous KC) with those with a low KC burden (&lt;2 previous KC). All patients were sensitized with 2% DPCP and then patch tested two weeks later with eight different concentrations of DPCP with the threshold concentration and total degree of reaction recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients were recruited, 5 in the \u2018high cancer\u2019 group and 4 in the \u2018low cancer\u2019 group. All patients were Fitzpatrick skin type 1 or 2. All patients developed a reaction to DPCP. Patients in the low cancer group developed a reaction at a significantly lower threshold DPCP concentration than the high cancer group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.039). The cumulative intensity of reaction was higher in the low cancer group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.087).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with a high KC burden required a higher threshold concentration of DPCP to elicit a hypersensitivity reaction, supporting the concept of a lower skin immunity in these patients. DPCP reactivity threshold could be a useful tool in the evaluation of skin immunity and propensity to develop keratinocyte cancers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15766","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T14:16:00Z","timestamp":1562076960000},"page":"2101-2105","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Level of contact hypersensitivity response to diphencyprone and keratinocyte cancer"],"prefix":"10.1111","volume":"33","author":[{"given":"A.","family":"Bullen","sequence":"first","affiliation":[{"name":"Department of Dermatology Princess Alexandra Hospital Brisbane Australia"},{"name":"Dermatology Research Centre The University of Queensland Diamantina Institute The University of Queensland Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Polcz","sequence":"additional","affiliation":[{"name":"Queensland Institute of Dermatology Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.J.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Princess Alexandra Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Byrom","sequence":"additional","affiliation":[{"name":"Department of Dermatology Princess Alexandra Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.P.","family":"Soyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Princess Alexandra Hospital Brisbane Australia"},{"name":"Dermatology Research Centre The University of Queensland Diamantina Institute The University of Queensland Brisbane Australia"},{"name":"Queensland Institute of Dermatology Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Khosrotehrani","sequence":"additional","affiliation":[{"name":"Department of Dermatology Princess Alexandra Hospital Brisbane Australia"},{"name":"Dermatology Research Centre The University of Queensland Diamantina Institute The University of Queensland Brisbane Australia"},{"name":"Queensland Institute of Dermatology Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Australian Institute of Health and Welfare 2016. Skin cancer in Australia. Cat. no. CAN 96. 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