{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:54:43Z","timestamp":1791284083059,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n From a dermatologist's perspective, there are four major types of cutaneous porphyrias (\n CP<\/jats:styled-content>\n s): porphyria cutanea tarda (\n PCT<\/jats:styled-content>\n ), erythropoietic protoporphyria (\n EPP<\/jats:styled-content>\n ), variegate porphyria (\n VP<\/jats:styled-content>\n ) and hereditary coproporphyria (\n HCP<\/jats:styled-content>\n ). Scarce data are available regarding the epidemiology of\n CP<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To describe the epidemiology of\n CP<\/jats:styled-content>\n s in Israel, including distribution, incidence and prevalence rates of major types.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective study includes all patients who were diagnosed with\n CP<\/jats:styled-content>\n s between the years 1988\u20132018. It is based on data from Israel's National Service for the Biochemical Diagnoses of Porphyrias, and Israeli patients\u2019 nationwide electronic medical charts. Incidence and prevalence rates were calculated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 173 patients with\n CP<\/jats:styled-content>\n s diagnosed during a 30\u2010year period, 65 (38%) had\n VP<\/jats:styled-content>\n , 62 (36%) had\n PCT<\/jats:styled-content>\n , 31 (18%) had\n HCP<\/jats:styled-content>\n and 15 (9%) had\n EPP<\/jats:styled-content>\n ; with incidence rates of 0.29, 0.30, 0.17, 0.07, and prevalence rates of 6.3, 4.8, 2.9, 1.6, respectively, per million population. Characteristics of patients with\n PCT<\/jats:styled-content>\n differed from those with other\n CP<\/jats:styled-content>\n s with regard to lack of family history, older mean age at diagnosis [51 vs. 36 (\n VP<\/jats:styled-content>\n ), 35 (\n HCP<\/jats:styled-content>\n ) and 25 (\n EPP<\/jats:styled-content>\n ) years] and male predominance (81% vs. similar distribution). All patients with\n PCT<\/jats:styled-content>\n were diagnosed at adulthood, while 20%, 19% and 15% of patients with\n VP<\/jats:styled-content>\n ,\n HCP<\/jats:styled-content>\n and\n EPP<\/jats:styled-content>\n , respectively, were diagnosed during childhood or adolescence.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Variegate porphyria and\n PCT<\/jats:styled-content>\n were found to be the most prevalent in Israel; however,\n CP<\/jats:styled-content>\n s might be underdiagnosed, thus dermatologists\u2019 awareness of these rare disorders is highly important.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.15769","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T03:20:02Z","timestamp":1562037602000},"page":"184-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epidemiology of cutaneous porphyria in Israel: a nationwide cohort study"],"prefix":"10.1111","volume":"34","author":[{"given":"Y.","family":"Edel","sequence":"first","affiliation":[{"name":"National Service for the Biochemical Diagnoses of Porphyrias Rabin Medical Center Beilinson Hospital Petach Tikva Israel"},{"name":"Rheumatology Unit Rabin Medical Center Beilinson Hospital Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mamet","sequence":"additional","affiliation":[{"name":"National Service for the Biochemical Diagnoses of Porphyrias Rabin Medical Center Beilinson Hospital Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-2193","authenticated-orcid":false,"given":"I.","family":"Snast","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Photodermatosis Clinic Department of Dermatology Beilinson Hospital Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kaftory","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mazor","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry School of Dental Medicine Hebrew University\u2010Hadassah Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hodak","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Photodermatosis Clinic Department of Dermatology Beilinson Hospital Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lapidoth","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Photodermatosis Clinic Department of Dermatology Beilinson Hospital Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Elis","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Department \u201cC\u201d of internal Belinson Hospital Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Molad","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Rabin Medical Center Beilinson Hospital Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Levi","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Photodermatosis Clinic Department of Dermatology Beilinson Hospital Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2015.04.034"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1608634"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5041\/rmmj.10333"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2444"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.7.500"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61925-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200276"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9544-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196574"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02794.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.703240"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70249-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13047"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.07.026"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0155-9"}],"container-title":["Journal 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