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Although many drugs have been used for the management of <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>, some of them lack the backup by strong therapeutic evidence, while others are not suitable for some patients due to safety profile issues. The aim of this study was to review the recent status of available medical therapies for <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> to help physicians make better decisions upon best medical practice while facing patients with this condition. A review of published articles on management of <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> was conducted with the <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> and PubMed databases. The quality of the evidence was graded as high, moderate, low or very low. A total of 1366 articles were retrieved, and 219 (16%) were included in the final analysis. Twenty\u2010one different treatment modalities were analysed. The quality of evidence was high for topical steroid and calcineurin inhibitor, while it was moderate for oral steroids. All the other modalities reached low or very low quality of evidence. Topical steroids and calcineurin inhibitors are the current first\u2010line therapies, while for other therapies the strength of recommendation is not so evident. Unfortunately, larger randomized, controlled trials to support the efficacy, safety and tolerability of other therapies in <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> are lacking, and many of them are recommended based on studies with small sample sizes, lack of standardized outcome measures or lack of controlled duration or even in anecdotal evidence. Thus, large\u2010scale randomized clinical trials are still warranted to establish the exact benefits of other topical treatments, phototherapy, immunosuppressant and new immunomodulators for an optimized treatment of <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jdv.15771","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T14:21:10Z","timestamp":1562077270000},"page":"1847-1862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Lichen planus: a comprehensive evidence\u2010based analysis of medical treatment"],"prefix":"10.1111","volume":"33","author":[{"given":"H.","family":"Husein\u2010ElAhmed","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Hospital de Baza Granada Spain"},{"name":"Translational Research Institute Academic Health System Medical School Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Gieler","sequence":"additional","affiliation":[{"name":"Translational Research Institute Academic Health System Medical School Hamad Medical Corporation Doha Qatar"},{"name":"Department of Dermatology and Venereology Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Steinhoff","sequence":"additional","affiliation":[{"name":"Translational Research Institute Academic Health System Medical School Hamad Medical Corporation Doha Qatar"},{"name":"Department of Dermatology and Venereology Hamad Medical Corporation Doha Qatar"},{"name":"College of Medicine Weill Cornell Medicine\u2010Qatar Doha Qatar"},{"name":"Medical School Qatar University Doha Qatar"},{"name":"College of Medicine Weill Cornell University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"e_1_2_27_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.66581"},{"key":"e_1_2_27_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06493.x"},{"key":"e_1_2_27_4_1","first-page":"801","volume-title":"Textbook of Pediatric Dermatology","author":"Solomon LM","year":"2006"},{"key":"e_1_2_27_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1984.tb01447.x"},{"key":"e_1_2_27_6_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.49.89"},{"key":"e_1_2_27_7_1","first-page":"273","article-title":"Lichen planus and hepatitis c virus (HCV)\u2010is there an association? 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