{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:16:33Z","timestamp":1792080993409,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cutaneous candidiasis is a common skin disease, and several treatments have been investigated within the last fifty years. Yet, systematic reviews are lacking, and evidence\u2010based topical and systemic treatment strategies remain unclear. Thus, the aim of this review was to summarize efficacy and adverse effects of topical and oral therapies for cutaneous candidiasis in all age groups. Two individual researchers searched PubMed and\n                    <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                    for \u2018cutaneous candidiasis\u2019 and \u2018cutaneous candidiasis treatment\u2019, \u2018intertrigo\u2019, \u2018diaper dermatitis\u2019 and \u2018cheilitis\u2019. Searches were limited to \u2018English language\u2019, \u2018clinical trials\u2019 and \u2018human subjects\u2019, and prospective clinical trials published in abstracts or articles were included. In total, 149 studies were identified, of which 44 were eligible, comprising 41 studies of 19 topical therapies and four studies of three systemic therapies for cutaneous candidiasis. Topical therapies were investigated in infants, children, adolescents, adults and elderly, while studies of systemic therapies were limited to adolescents and adults. Clotrimazole, nystatin and miconazole were the most studied topical drugs and demonstrated similar efficacy with complete cure rates of 73%\u2013100%. Single\u2010drug therapy was as effective as combinations of antifungal, antibacterial and topical corticosteroid. Four studies investigated systemic therapy, and oral fluconazole demonstrated similar efficacy to oral ketoconazole and topical clotrimazole. Limitations to this review were mainly that heterogeneity of studies hindered meta\u2010analyses. In conclusions, clotrimazole, nystatin and miconazole were the most studied topical drugs and demonstrated equal good efficacy and mild adverse effects similar to combinations of antifungal, antibacterial and topical corticosteroids. Oral fluconazole was as effective as topical clotrimazole and is the only commercially available evidence\u2010based option for systemic treatment of cutaneous candidiasis.\n                  <\/jats:p>","DOI":"10.1111\/jdv.15782","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T11:34:47Z","timestamp":1562672087000},"page":"1863-1873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Cutaneous candidiasis \u2013 an evidence\u2010based review of topical and systemic treatments to inform clinical practice"],"prefix":"10.1111","volume":"33","author":[{"given":"E.H.","family":"Taudorf","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Venereology Zealand University Hospital Roskilde Hospital Roskilde Denmark"},{"name":"Health Sciences Faculty University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.B.E.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology Zealand University Hospital Roskilde Hospital Roskilde Denmark"},{"name":"Health Sciences Faculty University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Hay","sequence":"additional","affiliation":[{"name":"Department of Dermatology King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.L.","family":"Saunte","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology Zealand University Hospital Roskilde Hospital Roskilde Denmark"},{"name":"Health Sciences Faculty University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3314\/mmj.56.J129"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000232390"},{"key":"e_1_2_6_4_1","unstructured":"Cutaneous candidiasis [WWW Document]. Medscape. URLhttps:\/\/emedicine.medscape.com"},{"key":"e_1_2_6_5_1","first-page":"s165","article-title":"Optimizing topical antifungal therapy for superficial cutaneous fungal infections: focus on topical naftifine for cutaneous dermatophytosis","volume":"12","author":"Del Rosso JQ","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/ddg.12420_suppl","article-title":"Mykologie ein update teil 2: dermatomykosen: klinisches bild und diagnostik","volume":"12","author":"Nenoff P","year":"2014","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.01.013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12360"},{"key":"e_1_2_6_9_1","unstructured":"Quality of evidence guidelines from Oxford Centre for Evidence\u2010based Medicine [WWW Document]. URLwww.cebm.net"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13781"},{"key":"e_1_2_6_11_1","first-page":"113","article-title":"Topical miconazole nitrate ointment in the treatment of diaper dermatitis complicated by candidiasis","volume":"77","author":"Spraker MK","year":"2006","journal-title":"Cutis"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1983.tb00245.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006058100900606"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1979.tb01592.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007997909109011"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.113.3.307"},{"key":"e_1_2_6_17_1","first-page":"39","article-title":"Topical treatment of inflammatory dermatoses and cutaneous candidiasis with a new cortico\u2010steroid \u2010antibiotic combination: halcinonide\u2010neomycin\u2010amphotericin","volume":"31","author":"Reyes\u2010Javier P","year":"1977","journal-title":"Br J Clin Pract"},{"key":"e_1_2_6_18_1","first-page":"126","article-title":"Cutaneous candidiasis: treatment with miconazole nitrate","volume":"19","author":"Cullin SI","year":"1977","journal-title":"Cutis"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007997709115274"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006057600400404"},{"key":"e_1_2_6_21_1","first-page":"655","article-title":"Clinical evaluation of a new halcinonide\u2010antifungal combination","volume":"20","author":"Barba\u2010Rubio J","year":"1976","journal-title":"Curr Ther Res Clin Exp"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2001.00632.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1976.tb01423.x"},{"key":"e_1_2_6_24_1","first-page":"412","article-title":"Topical treatment of dermatophytoses and candidoses","volume":"214","author":"Keczkes K","year":"1975","journal-title":"Practitioner"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000251929"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.110.1.81"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1973.tb02978.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1972.tb05079.x"},{"key":"e_1_2_6_29_1","first-page":"158","article-title":"Efficacy of nystatin topical cream in the management of cutaneous candidiasis in infants","volume":"14","author":"Alban J","year":"1972","journal-title":"Curr Ther Res Clin Exp"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-393X(98)85087-X"},{"key":"e_1_2_6_31_1","first-page":"35","article-title":"Efficacy and safety of 1% clotrimazole powder as an adjuvant therapy in patients with superficial fungal cutaneous infection in intertriginous areas","author":"Desomchoke R","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_6_32_1","first-page":"1106","article-title":"Naftifine cream 1% in cutaneous candidiasis","volume":"46","author":"Astorga E","year":"1989","journal-title":"Curr Ther Res Clin Exp"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246720"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-011-0253-0"},{"key":"e_1_2_6_35_1","first-page":"124","article-title":"Topical miconazole cream in infantile napkin dermatitis","volume":"222","author":"MacKie RM","year":"1979","journal-title":"Practitioner"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.018002149.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00757.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016358809004776"},{"key":"e_1_2_6_39_1","first-page":"757","article-title":"Phase II study of the therapeutic efficacy and safety of the new antimycotic sertaconazole in the treatment of superficial mycoses caused by Candida albicans","volume":"42","author":"Umbert P","year":"1992","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_6_40_1","first-page":"238","article-title":"Naftifine cream in the treatment of cutaneous candidiasis","volume":"42","author":"Zaias N","year":"1988","journal-title":"Cutis"},{"key":"e_1_2_6_41_1","first-page":"290","article-title":"Ciclopirox olamine lotion 1%: bioequivalence to ciclopirox olamine cream 1% and clinical efficacy in tinea pedis","volume":"11","author":"Aly R","year":"1989","journal-title":"Clin Ther"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000249647"},{"key":"e_1_2_6_43_1","first-page":"298","article-title":"Comparison of oxiconazole (Ro 13\u20108996) and econazole in dermatomycoses","volume":"27","author":"Gip L","year":"1984","journal-title":"Mykosen"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1983.tb02148.x"},{"key":"e_1_2_6_45_1","first-page":"29","article-title":"A multicenter, open\u2010label study to assess the safety and efficacy of ciclopirox topical suspension 0.77% in the treatment of diaper dermatitis due to Candida albicans","volume":"4","author":"Gallup E","year":"2005","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91149-O"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)80184-1"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1976.01630270030007"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1966.01600190107024"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80037-1"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.1994.37.9-10.361"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00541.x"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb01521.x"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475415574970"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2018-0059"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00309.x"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70192-5"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/43.4.579"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.15782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T11:42:32Z","timestamp":1693914152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,30]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/jdv.15782"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15782","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,30]]},"assertion":[{"value":"2019-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}