{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:35:16Z","timestamp":1791725716366,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin barrier dysfunction may precede infantile development of clinical atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>). Early\u2010life emollient therapy to enhance barrier function may prevent or modify <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> development in high\u2010risk infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>(a) To determine whether daily full\u2010body application of an emollient with ceramide and amino acids (study emollient) can reduce the cumulative <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> incidence compared to standard skin care at 1\u00a0year of age. (b) To evaluate the study emollient's effect on skin barrier function, natural moisturizing factor and the microbiome using non\u2010invasive biophysical and biochemical techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010centre, investigator\u2010blinded, randomized controlled trial enrolling infants at high risk for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> development determined by family history. The intervention was full\u2010body once\u2010daily application of the study emollient. The control arm was asked to not apply full\u2010body emollient regularly and only use an emollient of their choice for dry skin. The primary outcome was the cumulative incidence of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> diagnosed at 12\u00a0months by a blinded investigator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Less than half the target sample size was enrolled (<jats:italic>n<\/jats:italic>\u00a0=\u00a0100, goal sample was 208) with 28% lost to follow\u2010up. Across all clinical end points, a numerical trend was observed in favour of the intervention, although not statistically significant likely due to lack of power from under\u2010enrolment. <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was diagnosed in 13.2% vs. 25.0% at 12\u00a0months (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.204) and 19.4% vs. 31.0% at 2\u00a0years (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.296) in intervention vs. control groups, respectively. There were no significant differences between groups in skin barrier or microbiome assessments. While there were no serious adverse events, there were more cases of reported contact dermatitis in the intervention vs. control arms, 9.3% vs. 4.3%, respectively; however, these events were not related to the study emollient and most mild in severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The observed trends suggest a protective effect of daily study emollient therapy compared to control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15786","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T15:18:30Z","timestamp":1562685510000},"page":"2087-2094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["A randomized controlled trial of an emollient with ceramide and filaggrin\u2010associated amino acids for the primary prevention of atopic dermatitis in high\u2010risk infants"],"prefix":"10.1111","volume":"33","author":[{"given":"D.","family":"McClanahan","sequence":"first","affiliation":[{"name":"Oregon Health &amp; Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wong","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kezic","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Coronel Institute of Occupational Health Amsterdam Public Health Research Institute University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Samrao","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hajar","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hill","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.L.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039803"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ebch.827"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2433"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.12.013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.11.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.060"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15747"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01384.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-925.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719.2013.789881"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192443"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120608"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774514558307"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12424"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.15786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.15786","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:27:19Z","timestamp":1694240839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,30]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/jdv.15786"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15786","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,30]]},"assertion":[{"value":"2018-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}