{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:39:11Z","timestamp":1784774351507,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ungual warts are considered the most common benign nail tumour, and they are caused by the human papillomavirus. Despite the numerous treatments reported in the medical literature, ungual warts are considered frustrating, with high relapse rates and a potential risk of nail dystrophy. Bleomycin is a therapeutic option showing a good safety profile and high cure rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of electrochemotherapy using intralesional bleomycin for the treatment of ungual warts in comparison with intralesional bleomycin alone and describe the side\u2010effects related to the use of both techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, randomized, double\u2010blind, controlled clinical trial. Forty\u2010four 18\u2010 to 60\u2010year\u2010old female and male patients with ungual warts of only one finger were included. The patients were divided into two treatment groups: <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> \u2013 intralesional bleomycin; and <jats:styled-content style=\"fixed-case\">GB<\/jats:styled-content> \u2013 electroporation and intralesional bleomycin. Following a single application, the patients were followed up for 180\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients\u2019 mean age was 36\u00a0years for <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> and 37\u00a0years for <jats:styled-content style=\"fixed-case\">GB<\/jats:styled-content>. Most patients were female (68%). Of 22 patients in <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> completing the study, 11 (50%) achieved the cure, while 18 (85.7%) of 21 patients completing the study in <jats:styled-content style=\"fixed-case\">GB<\/jats:styled-content> showed cure. A significant association of patients with or without cure after the <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GB<\/jats:styled-content> treatments (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.022) was observed. None of the patients in either group had systemic side\u2010effects. Independent of the technique used, all the participants considered the adverse effects tolerable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The intralesional use of bleomycin associated with electroporation for the treatment of ungual warts (both periungual and subungual) showed a statistically superior cure when compared with intralesional bleomycin alone. Side\u2010effects were more frequently observed in the electrochemotherapy with bleomycin group than in the bleomycin monotherapy group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15815","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T20:18:55Z","timestamp":1563394735000},"page":"2349-2354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ungual warts: comparison of treatment with intralesional bleomycin and electroporation in terms of efficacy and safety"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5944-7737","authenticated-orcid":false,"given":"N.G.","family":"Di Chiacchio","sequence":"first","affiliation":[{"name":"Hospital do Servidor P\u00fablico Municipal de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Faculdade de Medicina do ABC Santo Andre 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