{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:53:47Z","timestamp":1791284027277,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Methylisothiazolinone (MI) has caused an unprecedented epidemic of contact allergy in Europe and elsewhere. Subsequently, regulatory action has been taken, at least in Europe, aiming at reducing risk of MI sensitization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To follow\u2010up on the prevalence of contact allergy to MI in consecutively patch tested patients and assess the spectrum of products containing MI or methylchloroisothiazolinone (MCI)\/MI in patients positive to MI which elicited current allergic contact dermatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional survey was performed in 2016 and 2017, including all adult patients patch tested with the baseline series (including MI 0.2% aq.) between 1 May and 31 October at 14 centres in 11 European countries. Patients with positive reactions (+ to +++) to MI were further examined regarding history, clinical characteristics and eliciting products, which were categorized into 34 types and 4 classes (leave\u2010on, rinse\u2010off, household, occupational). The results were compared with the reference year 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 317 patients,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0202 of 4278 tested in 2016 (4.72%) and\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0115 of 3879 tested in 2017 (2.96%), had positive reactions to MI; the previous result from 2015 was 5.97% (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.0001). The share of currently relevant contact allergy among all positive reactions declined significantly as well (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.0032). Concerning product classes, a relative decline of leave\u2010on and a relative increase of rinse\u2010off and household products was noted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of MI contact allergy decreased by 50% from 2015 to 2017. As a consequence of regulation, the share of cosmetics products (leave\u2010on in particular) eliciting allergic contact dermatitis is decreasing. The chosen method of analysing causative products in sensitized patients has proven useful to monitor effects of intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.15875","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T13:50:13Z","timestamp":1565963413000},"page":"333-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["The epidemic of methylisothiazolinone contact allergy in Europe: follow\u2010up on changing exposures"],"prefix":"10.1111","volume":"34","author":[{"given":"W.","family":"Uter","sequence":"first","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology University of Erlangen\/N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Aalto\u2010Korte","sequence":"additional","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Agner","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"Bircher","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Brans","sequence":"additional","affiliation":[{"name":"Institute for Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabr\u00fcck Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.L.","family":"Diepgen","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, Occupational and Environmental Dermatology University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Foti","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Department of Biomedical Science and Human Oncology University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gim\u00e9nez Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar IMIM Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gon\u00e7alo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital and Faculty of Medicine University of Coimbra Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Goossens","sequence":"additional","affiliation":[{"name":"Contact Allergy Unit Department of Dermatology University Hospital KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"McFadden","sequence":"additional","affiliation":[{"name":"Guy's Hospital St John's Institute of Dermatology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Rustemeyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Amsterdam University Medical Centres Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.R.","family":"White","sequence":"additional","affiliation":[{"name":"Guy's Hospital St John's Institute of Dermatology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the European Environmental Contact Dermatitis Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00205.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12705"},{"key":"e_1_2_6_4_1","unstructured":"SCCS.Scientific committee on consumer safety opinion on methylisothiazolinone(p94) \u2013 submission ii 12 December 2013 sccs\/1521\/13 revision of 27 march 2014. 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