{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:28:29Z","timestamp":1781760509043,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the burden, predictors and temporal relationships of comorbidities in patients with hidradenitis suppurativa (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Information on <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> and ten systemic comorbidities was obtained by interview and clinical examination, including blood pressure, body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and blood samples, in a cohort of consecutive <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> outpatients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 302 patients were included. About 86.6% had at least one comorbidity. The mean number of comorbidities per patient was 2.1. One or more cardiovascular comorbidities were observed in 76.5% with evidence of substantial unawareness and undertreatment; 48.4% had hypertension, 9.3% had diabetes, 57.7% had dyslipidaemia and 36.7% were obese. About 6.6% had inflammatory bowel disease, 6.3% had arthritis, 29.5% had a psychiatric diagnosis, 5.6% had psoriasis, 7.9% had obstructive lung disease, and 6.6% had polycystic ovary syndrome. These comorbidities occurred at different time points in relation to the onset of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> with evidence of shared as well as differential risk factors. Age (per year), <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a00.87 (0.79\u20130.96), <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.006, age of onset of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> (per year), <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01.26 (1.14\u20131.40), <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001, male sex, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a02.51 (0.88\u20137.16), <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.086, Hurley stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (vs. Hurley I\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a03.46 (1.25\u20139.58), <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.017, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (per unit), <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01.12 (1.04\u20131.20), <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002, and blood glucose (per unit), <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01.27 (1.16\u20131.39), <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001 were significant predictors for onset of diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a substantial burden, unawareness and undertreatment of several systemic comorbidities in patients with <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>. Comorbidities occur at different time points in relation to the onset of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>. This should lead to higher awareness among treating specialists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15904","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T19:55:51Z","timestamp":1566590151000},"page":"565-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Burden, predictors and temporal relationships of comorbidities in patients with hidradenitis suppurativa: a hospital\u2010based cohort study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4256-116X","authenticated-orcid":false,"given":"A.\u2010H.R.","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Venereology &amp; Wound Healing Centre Bispebjerg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of 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