{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:53:35Z","timestamp":1791284015466,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In melanoma, preclinical data suggest a possible role of polyunsaturated fatty acids inhibiting cell growth. A new target molecule for free fatty acids, the G protein\u2010coupled receptor\n                      <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                      40, was identified in melanoma cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to investigate\n                      <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                      40 expression in human melanocytic tissues and to evaluate its potential as a prognostic marker.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      A total of 114 tissue sections of naevi, primary melanoma and melanoma metastasis were immunohistochemically stained with anti\u2010\n                      <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                      40. The staining was evaluated, using the immunoreactivity scoring system. Compared to naevi, primary melanoma and melanoma metastasis showed significantly higher levels of\n                      <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                      40 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). In primary melanoma,\n                      <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                      40 expression positively correlated with tumour thickness (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.044) and\n                      <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content>\n                      level (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.017) and in melanoma metastasis with\n                      <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content>\n                      level (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.035). Primary melanoma patients with high levels of\n                      <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                      40 had a significantly poorer overall survival (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004) and shorter disease\u2010free survival (0.040).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The present study identified\n                      <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                      40 as a novel target molecule in melanoma. First evidence for a potential role of the receptor in tumour progression and metastases was found, and it could be demonstrated that\n                      <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                      40 expression is negatively correlated with patient's survival.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.15924","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T14:54:33Z","timestamp":1567090473000},"page":"285-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["G protein\u2010coupled receptor 40 expression in human melanoma \u2013 correlation with tumour thickness,\n                    <scp>AJCC<\/scp>\n                    stage and survival"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2005-5282","authenticated-orcid":false,"given":"J.","family":"Kleemann","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergy Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Hrgovic","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergy Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kleimann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergy Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ter\u2010Nedden","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergy Goethe 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