{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:00:30Z","timestamp":1774987230771,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lentigo maligna (LM) is an in\u00a0situ form of melanoma carrying a risk of progression to invasive lentigo maligna melanoma (LMM). LM poses a clinical challenge, with subclinical extension and high recurrence rates after incomplete surgery. Alternative treatment methods have been investigated with varying results. Photodynamic therapy (PDT) with methylaminolaevulinate (MAL) has already proved promising in this respect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the efficacy of ablative fractional laser (AFL)\u2010assisted PDT with 5\u2010aminolaevulinic acid nanoemulsion (BF\u2010200 ALA) for treating LM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this non\u2010sponsored prospective pilot study, ten histologically verified LMs were treated with AFL\u2010assisted PDT three times at 2\u2010week intervals using a light dose of 90\u00a0J\/cm<jats:sup>2<\/jats:sup> per treatment session. Local anaesthesia with ropivacaine was used. Four weeks after the last PDT treatment the lesions were treated surgically with a wide excision and sent for histopathological examination. The primary outcome was complete histopathological clearance of the LM from the surgical specimen. Patient\u2010reported pain during illumination and the severity of the skin reaction after the PDT treatments were monitored as secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The complete histopathological clearance rate was 7 out of 10 LMs (70%). The pain during illumination was tolerable, with the mean pain scores for the PDT sessions on a visual assessment scale ranging from 2.9 to 3.8. Some severe skin reactions occurred during the treatment period, however.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ablative fractional laser\u2010assisted PDT showed moderate efficacy in terms of histological clearance. It could constitute an alternative treatment for LM but due to the side effects it should only be considered in inoperable cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15925","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T17:58:48Z","timestamp":1567101528000},"page":"510-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ablative fractional laser\u2010assisted photodynamic therapy for lentigo maligna: a prospective pilot study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3809-384X","authenticated-orcid":false,"given":"J.E.","family":"R\u00e4s\u00e4nen","sequence":"first","affiliation":[{"name":"Department of Dermatology P\u00e4ij\u00e4t\u2010H\u00e4me Social and Health Care Group Lahti Finland"},{"name":"Department of Dermatology Faculty of Medicine and Medical Technology Tampere University Hospital and Tampere University Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8733-5510","authenticated-orcid":false,"given":"N.","family":"Neittaanm\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Pathology and Dermatology Institute of Biomedicine and Clinical Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jeskanen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki and HUSLAB Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"P\u00f6l\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Mathematical Information Technology University of Jyv\u00e4skyl\u00e4 Jyv\u00e4skyl\u00e4 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