{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:53:18Z","timestamp":1791283998941,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Chronic viral infections caused by highly contagious human papillomaviruses (\n HPV<\/jats:styled-content>\n s) from the alpha genus are a substantial risk factor for tumour diseases.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n The goal of this study was to compare the\n HPV<\/jats:styled-content>\n infection pattern with histology in a patient group of immunocompromised\n HIV<\/jats:styled-content>\n +<\/jats:sup>\n and non\u2010immunocompromised patients with anal intraepithelial neoplasia.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Tissue samples (\n n<\/jats:italic>\n \u00a0=\u00a0210) from the anogenital area of 121 patients underwent retrospective histological and molecular examination for\n HPV DNA<\/jats:styled-content>\n prevalence by chip analysis. The study was part of a cancer screening from the Dermatology Department of the\n LMU<\/jats:styled-content>\n Munich, Germany. All data were collected and processed anonymously.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n HPV<\/jats:styled-content>\n 6 or 11 are more abundant in tissue samples from histologically diagnosed condylomata acuminata (47.7%) compared to grade 1, 2, and 3 intraepithelial neoplasias (\n IN<\/jats:styled-content>\n 1\u20103). Detection of high\u2010risk (hr) alpha\u2010\n HPV DNA<\/jats:styled-content>\n was significantly higher in tissue samples from\n IN<\/jats:styled-content>\n 3 (67.5%) compared to\n IN<\/jats:styled-content>\n 1 and 2 (12.9%), and compared to condylomata acuminata (29.5%). No\n HPV<\/jats:styled-content>\n types were detected in histologically unremarkable tissue samples. There was a significant association between the prevalence of\n HPV<\/jats:styled-content>\n 16 and the classifications\n IN<\/jats:styled-content>\n 1 to\n IN<\/jats:styled-content>\n 3 (\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n (2)\u00a0=\u00a013.62,\n P<\/jats:italic>\n \u00a0=\u00a00.001). We identified a significant correlation between the prevalence of high\u2010risk and low\u2010risk (lr)\n HPV<\/jats:styled-content>\n types and\n HIV<\/jats:styled-content>\n , especially mixed infections of different\n HPV<\/jats:styled-content>\n types correlated with high\u2010grade\n IN<\/jats:styled-content>\n . Based on the present data, we suggest the risk of carcinoma in\n HIV<\/jats:styled-content>\n +\/\u2212<\/jats:sup>\n patients (\n RICH<\/jats:styled-content>\n ) score and test it in the 121 patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n hr alpha\u2010\n HPV<\/jats:styled-content>\n s, mainly\n HPV<\/jats:styled-content>\n 16, are associated with increased oncogenic potential of premalignant lesions (\n IN<\/jats:styled-content>\n 1\u20103), especially in\n HIV<\/jats:styled-content>\n +<\/jats:sup>\n patients. Based on the combination of\n HIV<\/jats:styled-content>\n \/\n HPV<\/jats:styled-content>\n \u2010testing and histological analysis, we identified correlations that could potentially forecast the risk of malignant transformation and summarized them in the form of\n RICH<\/jats:styled-content>\n score.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.15932","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T09:34:21Z","timestamp":1567935261000},"page":"377-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Retrospective analysis of alpha\u2010human papillomavirus (\n HPV<\/scp>\n ) types in tissue samples from anogenital dysplasias \u2013 introduction of the\n RICH<\/scp>\n (Risk of\n HPV<\/scp>\n \u2010related Carcinoma in\n HIV<\/scp>\n +\/\u2212<\/sup>\n patients) score"],"prefix":"10.1111","volume":"34","author":[{"given":"J.A.","family":"Hildebrand","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of Munich (LMU) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"Fischbeck","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of Munich (LMU) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hundsdoerfer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of Munich (LMU) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.M.","family":"Clanner\u2010Engelshofen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of Munich (LMU) Munich 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