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Most of the previous articles evaluated the overall efficacy of existing\n                      <jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>\n                      inhibitors rather than evaluating one of them alone. Currently, the benefit and risk profile of tofacitinib for the treatment of\n                      <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                      is still not clear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To estimate the safety and efficacy of tofacitinib in patients with\n                      <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                      based on summarizing the clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The systematic review and meta\u2010analysis was performed according to\n                      <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>\n                      guidelines.\n                      <jats:styled-content style=\"fixed-case\">ROBINS<\/jats:styled-content>\n                      \u2010I (Risk of Bias in Non\u2010randomized Studies\u2010of Interventions) was used for quality assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 14 studies including six clinical trials and eight observational studies with 275 patients. The result of meta\u2010analysis showed that tofacitinib has reasonable effectiveness in patients with\n                      <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                      . The pooled good\/complete hair regrowth rate of tofacitinib treating patient with\n                      <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                      was 54.0% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 46.3%\u201361.5%), and the pooled rate of partial response in patients with\n                      <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                      taking tofacitinib was 26.1% (20.7\u201332.2%). Approximately a quarter of patients had experience of relapse, most of which was reported due to discontinuation of tofacitinib. In terms of toxicity, reported adverse effects included only mild symptoms. Upper respiratory infection, headache and acne were the most common adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Tofacitinib seems to be a promising drug for the treatment of\n                      <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                      with only mild adverse effects. More thorough larger sized randomized clinical trials are required to further assess the safety and clinical efficacy of tofacitinib for the treatment of\n                      <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.15937","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T09:41:48Z","timestamp":1567935708000},"page":"192-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Benefit and risk profile of tofacitinib for the treatment of alopecia areata: a systemic review and meta\u2010analysis"],"prefix":"10.1111","volume":"34","author":[{"given":"L.","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pharmacology West China School of Basic Sciences &amp; Forensic Medicine Animal Research Institute Sichuan University Chengdu 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