{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:53:18Z","timestamp":1791283998953,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Patients with rosacea or demodicosis have high facial skin Demodex densities (Dds). Topical ivermectin, benzyl benzoate (\n                      <jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>\n                      ) and crotamiton have been shown to decrease Dds\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      , but there are few data on the clinical and acaricidal effects of\n                      <jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>\n                      among patients with rosacea.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the impact of topical\n                      <jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>\n                      (+crotamiton) treatment on Dds and clinical symptoms of rosacea and demodicosis, and compare three\n                      <jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>\n                      treatment regimens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective observational study, 394 patients (117 with rosacea, 277 with demodicosis) were included. Three\n                      <jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>\n                      (+crotamiton) treatment regimens were compared: 12% once daily, 12% twice daily and 20% once daily. Dds were measured using two consecutive standardized skin surface biopsies [superficial (\n                      <jats:styled-content style=\"fixed-case\">SSSB<\/jats:styled-content>\n                      1) and deep (\n                      <jats:styled-content style=\"fixed-case\">SSSB<\/jats:styled-content>\n                      2)] before treatment and at the first follow\u2010up. Symptoms were evaluated using investigator global assessment. Treatment was considered effective if the Dd had normalized (\n                      <jats:styled-content style=\"fixed-case\">SSSB<\/jats:styled-content>\n                      1\u00a0\u2264\u00a05\u00a0D\/cm\n                      <jats:sup>2<\/jats:sup>\n                      <jats:styled-content style=\"fixed-case\">AND SSSB<\/jats:styled-content>\n                      2\u00a0\u2264\u00a010\u00a0D\/cm\u00b2) or symptoms had cleared and curative if the Dd had normalized and symptoms had cleared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At an average of 2.7\u00a0months after treatment start, the total Dd (\n                      <jats:styled-content style=\"fixed-case\">SSSB<\/jats:styled-content>\n                      1\u00a0+\u00a02) had decreased by 72.4\u00a0\u00b1\u00a02.6% from the initial value across the whole cohort. Dds had normalized in 139 patients (35%), and symptoms had cleared in 122 (31%). Treatment was effective in 183 (46%) patients and curative in 78 (20%). Compliance was good: 77% of patients correctly followed treatment instructions. Results were similar in patients with rosacea and those with demodicosis. The 12% once\u2010daily regimen was less effective than the other doses and had poorer compliance than the 12% twice\u2010daily regimen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Topical treatment with\n                      <jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>\n                      (+crotamiton) may be an effective treatment for rosacea and demodicosis, indirectly supporting a key role of the mite in the pathophysiology of rosacea. The two higher dose regimens were more effective than the lower dose.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.15938","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T02:54:10Z","timestamp":1567911250000},"page":"365-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Treatment of rosacea and demodicosis with benzyl benzoate: effects of different doses on Demodex density and clinical symptoms"],"prefix":"10.1111","volume":"34","author":[{"given":"F.M.N.","family":"Forton","sequence":"first","affiliation":[{"name":"Dermatology Clinic Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"De Maertelaer","sequence":"additional","affiliation":[{"name":"Institut de Recherche Interdisciplinaire en Biologie humaine et mol\u00e9culaire (IRIBHM) &amp; Service de Biostatistique et Informatique m\u00e9dicale (SBIM) Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"419","article-title":"An epidemiological study of rosacea","volume":"69","author":"Berg M","year":"1989","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.05.034"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12850"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15122"},{"key":"e_1_2_6_6_1","first-page":"20","article-title":"Demodex dermatitis: a retrospective analysis of clinical diagnosis and successful treatment with topical crotamiton","volume":"2","author":"Bikowski JB","year":"2009","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16540"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00331.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12030"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2528"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04310.x"},{"issue":"6","key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/ddg.13143","article-title":"Rosacea Management: update on general measures and topical treatment options","volume":"14","author":"Schaller M","year":"2016","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2819-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13408"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02125.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12178"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14437"},{"key":"e_1_2_6_18_1","first-page":"316","article-title":"Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double\u2010blind, vehicle\u2010controlled pivotal studies","volume":"13","author":"Stein Gold LS","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17817"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.01.048"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S139352"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.15938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.15938","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:16:51Z","timestamp":1791281811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,17]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/jdv.15938"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15938","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,17]]},"assertion":[{"value":"2019-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}