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It is used in various cosmetic products to either provide an appropriate sun protection factor in sunscreen products or to protect cosmetic formulations from <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> radiation. There is no discussion that <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> filters are beneficial ingredients in cosmetics since they protect from skin cancer, but octocrylene has been recently incriminated to potentially induce adverse effects on the endocrine system in addition to having allergic and\/or photoallergic potential. However, the substance has the advantage to work synergistically with other filters allowing a beneficial broad photoprotection, e.g. it stabilizes the <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> filter avobenzone (i.e. butylmethoxydibenzoylmethane). Like all chemicals used in cosmetics, the safety profile of octocrylene is constantly under assessment by the European Chemical Agency (ECHA) since it has been registered according to the European regulation Registration, Evaluation, Authorisation and Restriction of Chemicals. Summaries of safety data of octocrylene are publicly available on the <jats:styled-content style=\"fixed-case\">ECHA<\/jats:styled-content> website. This review aims to present the main safety data from the <jats:styled-content style=\"fixed-case\">ECHA<\/jats:styled-content> website, as well as those reported in scientific articles from peer\u2010reviewed journals. The available data show that octocrylene does not have any endocrine disruption potential. It is a rare sensitizer, photocontact allergy is more frequent and it is considered consecutive to photosensitization to ketoprofen. Based on these results, octocrylene can be considered as safe when used as a <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> filter in cosmetic products at a concentration up to 10%.<\/jats:p>","DOI":"10.1111\/jdv.15945","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T07:58:21Z","timestamp":1570435101000},"page":"25-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Review of the safety of octocrylene used as an ultraviolet filter in cosmetics"],"prefix":"10.1111","volume":"33","author":[{"given":"E.","family":"Berardesca","sequence":"first","affiliation":[{"name":"Phillip Frost Dept. of Dermatology University of Miami Miller School of Medicine Miami USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Zuberbier","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sanchez Viera","sequence":"additional","affiliation":[{"name":"Instituto De Dermatologia Integral Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marinovich","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences University of Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13372"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b03996"},{"key":"e_1_2_10_4_1","unstructured":"Danish Environmental Protection Agency.Survey and health assessment of UV filters.Danish Environmental Protection Agency 2015."},{"key":"e_1_2_10_5_1","unstructured":"AxelstadM HassU KinnbergK BjerregaardP.Assessment of the endocrine disrupting potential of 23 UV\u2010filters (j.no. 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