{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:26:42Z","timestamp":1774657602372,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"S8","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Usually, <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> lesions are surrounded by a number of clinically visible and non\u2010visible (subclinical) areas of actinically damaged skin containing cells with dysplasia, and thus may be designated actinic dysplasia syndrome. The epithelial damage is caused mainly by <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> radiation, inducing mutations in keratinocytes that may confer growth advantages resulting in preneoplastic fields. The development of visible dysplastic lesions (actinic keratosis \u2013 <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>) and subsequent progression to invasive <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> requires further mutations in cancer\u2010associated genes, like tumour suppressor genes and cell cycle regulators. Reflectance confocal microscopy (<jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>) and optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) represent a considerable advantage for the investigation of field cancerization. In addition, imaging allows the non\u2010invasive monitoring of topical treatments for <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s. <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> provides <jats:italic>in\u00a0vivo<\/jats:italic> horizontal skin sections with a high, 1\u2010\u03bcm lateral resolution (similar to histopathology) but with a limited penetration (about 200\u00a0\u03bcm), which can hamper the visualization of important areas such as the dermal\u2013epidermal junction. Conventional <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> has better penetration (1\u20132\u00a0mm) at the expense of a more limited resolution (much lower than histopathology). Line\u2010field confocal <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) combines the high precision of <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> and the good penetration of <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> in a single device and therefore appears to be very useful in diagnosing\/managing <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/jdv.15949","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T10:23:39Z","timestamp":1576232619000},"page":"16-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The actinic dysplasia syndrome \u2013 diagnostic approaches defining a new concept in field carcinogenesis with multiple <scp>cSCC<\/scp>"],"prefix":"10.1111","volume":"33","author":[{"given":"G.","family":"Dejonckheere","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology Erasme Hospital Free University of Brussels Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Suppa","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Erasme Hospital Free University of Brussels Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"del Marmol","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Erasme Hospital Free University of Brussels Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6711-3809","authenticated-orcid":false,"given":"T.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology St. Josef Hospital Ruhr\u2010University Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Stockfleth","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology St. Josef Hospital Ruhr\u2010University Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q"},{"key":"e_1_2_5_3_1","first-page":"1727","article-title":"A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications","volume":"63","author":"Braakhuis BJ","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72589"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.14025"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.302"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1122"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.492"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3228"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.048"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa6806"},{"key":"e_1_2_5_12_1","first-page":"415","article-title":"Actinic keratosis as a marker of field cancerization in excision specimens of cutaneous malignancies","volume":"97","author":"Lanoue J","year":"2016","journal-title":"Cutis"},{"key":"e_1_2_5_13_1","first-page":"18","article-title":"Defining field cancerization of the skin using noninvasive optical coherence tomography imaging to detect and monitor actinic keratosis in ingenol mebutate 0.015% \u2013 treated patients","volume":"9","author":"Markowitz O","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12848"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16536"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03025-1"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14514"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.05.028"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07860.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07426.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08275.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.134"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70072-0"},{"key":"e_1_2_5_24_1","first-page":"603","article-title":"Optical coherence tomography in dermatology","volume":"150","author":"Olsen J","year":"2015","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.23.10.106007"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines6010008"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.02.033"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13720"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13445"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.15949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.15949","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:29:40Z","timestamp":1693351780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":28,"journal-issue":{"issue":"S8","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/jdv.15949"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15949","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"2019-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}