{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:27:12Z","timestamp":1788791232995,"version":"build-2803163510"},"reference-count":82,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current treatment paradigms in anti\u2010p200 pemphigoid rely on low levels of evidence, primarily originating from case reports and case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To\u00a0systematically review the utilized treatment modalities for anti\u2010p200 pemphigoid and to synthesize the available clinical outcomes of treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review of the literature using Ovid\u2010Medline (1946\u20132018), Embase (1947\u20132018) and Web of Science (1900\u20132018) databases with a broad and inclusive search strategy along with a subsequent search of retrieved articles. All case reports and case series of patients with anti\u2010p200 pemphigoid were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010eight eligible studies comprising 113 anti\u2010p200 pemphigoid patients with a mean age of 65.5\u00a0years were included in the qualitative synthesis. The clinical outcome of patients following treatment was reported for 91 (80.5%) patients, of whom 83 (91.2%) had achieved complete remission at least once. Complete remission on\u2010therapy was observed in 51 (56.0%) and complete remission off\u2010therapy in 12 (13.2%) patients. Thirty\u2010six (39.6%) patients had experienced at least one flare during the duration of follow\u2010up. A combination of systemic corticosteroids and adjuvant immunomodulatory agents was the leading therapeutic approach (63.0%) required for disease control. Systemic and topical corticosteroids as monotherapy were sufficient to control the disease in 19.6% and 13.0% of cases, respectively. Dapsone was the most commonly used (41.3%) adjuvant agent. The highest rates of complete remission were achieved in patients managed by systemic corticosteroids as monotherapy (100%) and in those managed by systemic corticosteroids with adjuvant agents (90.7%). Conversely, 45.5% of patients treated only by topical corticosteroids experienced at least one relapse during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The vast majority of patients had reached a complete remission during the course of the disease, whereas a considerable proportion of patients experienced at least one relapse. A combination of systemic corticosteroids and adjuvant immunomodulatory agents was the most frequently utilized therapeutic approach.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15961","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T18:24:27Z","timestamp":1568917467000},"page":"465-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Treatment and clinical outcomes in anti\u2010p200 pemphigoid: a systematic review"],"prefix":"10.1111","volume":"34","author":[{"given":"R.","family":"Laufer Britva","sequence":"first","affiliation":[{"name":"Department of Dermatology Rambam Health Care Campus Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.T.","family":"Amber","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Illinois at Chicago Chicago IL 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