{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:40:51Z","timestamp":1761864051496,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several treatment options are currently available for the treatment of psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the main associations between patients\u2019 characteristics and systemic treatments prescribed for psoriasis in a large group of patients observed in real\u2010life clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of baseline data collected within the Swiss Dermatology Network for Targeted Therapies registry in Switzerland between March 2011 and December 2017. Semantic map analysis was used in order to capture the best associations between variables taking into account other covariates in the system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 549 patients (mean age 46.7\u00a0\u00b1\u00a014.7\u00a0years) were included in the analysis. Conventional therapies such as retinoids and methotrexate were associated with no previous systemic therapies for psoriasis, a moderate quality of life (QoL) at therapy onset and older age (\u226560\u00a0years). Fumaric acid derivatives were associated with mild psoriasis (psoriasis area severity index\u00a0&lt;\u00a010) and long disease duration (\u226520\u00a0years). On the other side, cyclosporine and psoralen and ultraviolet A\/ultraviolet B treatments were linked to a more severe condition, including impaired QoL, hospitalization and inability to work. Regarding biological therapies, both infliximab and adalimumab were connected to the presence of psoriatic arthritis, severe disease condition and other comorbidities, including chronic liver or kidney diseases and tuberculosis. Etanercept, ustekinumab and secukinumab were all connected to a complex history of previous systemic treatments for psoriasis, moderate disease condition, overweight and university education.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The analysis shows multifaceted associations between patients\u2019 characteristics, comorbidities, disease severity and systemic treatments prescribed for psoriasis. In particular, our semantic map indicates that comorbidities play a central role in decision\u2010making of systemic treatments usage for psoriasis. Future studies should further investigate specific connections emerging from our data.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15983","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T20:10:43Z","timestamp":1569701443000},"page":"2313-2318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Linkage between patients\u2019 characteristics and prescribed systemic treatments for psoriasis: a semantic connectivity map analysis of the Swiss Dermatology Network for Targeted Therapies registry"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-6138","authenticated-orcid":false,"given":"S.","family":"Cazzaniga","sequence":"first","affiliation":[{"name":"Department of Dermatology, Inselspital Bern University Hospital University of Bern Bern Switzerland"},{"name":"Centro Studi GISED Bergamo Italy"},{"name":"Graduate School for Cellular and Biomedical Sciences University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-0626","authenticated-orcid":false,"given":"F.","family":"Anzengruber","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-8728","authenticated-orcid":false,"given":"M.","family":"Augustin","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.H.","family":"Boehncke","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology University Hospital of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0424-6297","authenticated-orcid":false,"given":"L.","family":"Borradori","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Conrad","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology H\u00f4pital de Beaumont Lausanne University Hospital Center Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cozzio","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology and Allergology Cantonal Hospital St Gallen St Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Djamei","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.E.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"},{"name":"Department of Dermatology and Allergy University Hospital LMU Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gilliet","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology H\u00f4pital de Beaumont Lausanne University Hospital Center Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"H\u00e4usermann","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Basel Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Heidemeyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Itin","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Basel Hospital Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.G.A.","family":"Kolios","sequence":"additional","affiliation":[{"name":"Department of Immunology University Hospital Zurich Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Laffitte","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology University Hospital of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010T.","family":"Maul","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mainetti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Regional Hospital Bellinzona Bellinzona Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Naldi","sequence":"additional","affiliation":[{"name":"Centro Studi GISED Bergamo Italy"},{"name":"Department of Dermatology Azienda USL 8 Berica \u2010 San Bortolo Hospital Vicenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Navarini","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.J.","family":"Rustenbach","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sorbe","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Streit","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Cantonal Hospital Aarau Aarau Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Yawalkar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092283"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075044"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"e_1_2_5_5_1","first-page":"67","article-title":"Psoriasis: epidemiology, natural history, and differential diagnosis","volume":"2","author":"Basko\u2010Plluska JL","year":"2012","journal-title":"Psoriasis"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10280.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23681.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.064"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.09.004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13354"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12344"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445681"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475418814234"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455042"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452740"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15660"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15191"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139164849"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2586"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15234"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15019"},{"key":"e_1_2_5_22_1","first-page":"293","article-title":"Comparison of guidelines for the use of cyclosporine for psoriasis: a critical appraisal and comprehensive review","volume":"15","author":"Soleymani T","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0015-y"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta15100"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2013.768530"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i46.17352"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.026"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.878449"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16705"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.06.057"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.15983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.15983","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T08:39:25Z","timestamp":1694075965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,28]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/jdv.15983"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15983","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"type":"print","value":"0926-9959"},{"type":"electronic","value":"1468-3083"}],"subject":[],"published":{"date-parts":[[2019,10,28]]},"assertion":[{"value":"2019-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}