{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:13:15Z","timestamp":1789589595144,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cross\u2010reactivity among beta\u2010lactam antibiotics (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>) is essentially reported in immediate hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate cross\u2010reactivity beyond <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>s in patients with non\u2010immediate cutaneous adverse drug reaction (non\u2010immediate <jats:styled-content style=\"fixed-case\">CADR<\/jats:styled-content>) managed in a dermatology reference centre of toxic bullous and severe <jats:styled-content style=\"fixed-case\">CADR<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Materials\/Methods<\/jats:title><jats:p>We conducted a retrospective single\u2010centre study in consecutive patients consulting between 2010 and 2018 with an active <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\u2010suspected non\u2010immediate <jats:styled-content style=\"fixed-case\">CADR<\/jats:styled-content> and explored by cutaneous tests [patch tests (<jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>) and intradermal tests (P\u2010<jats:styled-content style=\"fixed-case\">IDR<\/jats:styled-content>)] for at least three penicillin's subclasses and amino\u2010 and non\u2010amino\u2010cephalosporins (at least one aminocephalosporin). Cross\u2010reactivity among subclasses was investigated for patients with positive tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 56 patients, among whom 46 amoxicillin\u2010suspected were and seven cephalosporin\u2010suspected. Twenty\u2010nine had severe <jats:styled-content style=\"fixed-case\">CADR<\/jats:styled-content>, and 27 had non\u2010immediate maculopapular exanthema (<jats:styled-content style=\"fixed-case\">MPE<\/jats:styled-content>). Twenty\u2010two had positive tests (18 for <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and four for <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>). Among the 18 positive amoxicillin\u2010suspected, 10 (55.6%) showed cross\u2010reactivity with one or more other <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>: 9 (50%) with another penicillin and 3 (16.5%) with a non\u2010aminocephalosporin. No amoxicillin\u2010 or cephalosporin\u2010suspected patient showed cross\u2010reactivity with aztreonam or carbapenems. P\u2010<jats:styled-content style=\"fixed-case\">IDR<\/jats:styled-content> showed cross\u2010reactivity only once.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After a suspected <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\u2010induced non\u2010immediate <jats:styled-content style=\"fixed-case\">CADR<\/jats:styled-content>, a large allergologic exploration is needed to confirm the diagnosis and evaluate cross\u2010reactivity. In our population including cases of severe <jats:styled-content style=\"fixed-case\">CADR<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">MPE<\/jats:styled-content> with late delay of onset, cross\u2010reactivity was frequent and <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> was sufficient to this purpose. The frequent cross\u2010reactivity among penicillins encourages stopping this whole family and to test cephalosporins, aztreonam and carbapenems for which cross\u2010allergies are rarer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15986","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T06:23:28Z","timestamp":1569911008000},"page":"787-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cross\u2010reactivity in beta\u2010lactams after a non\u2010immediate cutaneous adverse reaction: experience of a reference centre for toxic bullous diseases and severe cutaneous adverse reactions"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9582-4648","authenticated-orcid":false,"given":"V.","family":"B\u00e9rot","sequence":"first","affiliation":[{"name":"Dermatology Department APHP Henri Mondor Hospital Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gener","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP Henri Mondor Hospital Cr\u00e9teil France"},{"name":"Reference Center for Toxic Bullous Diseases and Severe Cutaneous Adverse Reactions Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ingen\u2010Housz\u2010Oro","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP Henri Mondor Hospital Cr\u00e9teil France"},{"name":"Reference Center for Toxic Bullous Diseases and Severe Cutaneous Adverse Reactions Cr\u00e9teil France"},{"name":"EA7379 EpidermE UPEC Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Gaudin","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP Henri Mondor Hospital Cr\u00e9teil France"},{"name":"Reference Center for Toxic Bullous Diseases and Severe Cutaneous Adverse Reactions Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Paul","sequence":"additional","affiliation":[{"name":"EA7379 EpidermE UPEC Cr\u00e9teil France"},{"name":"Department of Pharmacy AP\u2010HP H\u00f4pital Henri\u2010Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Chosidow","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP Henri Mondor Hospital Cr\u00e9teil France"},{"name":"Reference Center for Toxic Bullous Diseases and Severe Cutaneous Adverse Reactions Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est Cr\u00e9teil Val de Marne UPEC Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Wolkenstein","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP Henri Mondor Hospital Cr\u00e9teil France"},{"name":"Reference Center for Toxic Bullous Diseases and Severe Cutaneous Adverse Reactions Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est Cr\u00e9teil Val de Marne UPEC Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Assier","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP Henri Mondor Hospital Cr\u00e9teil France"},{"name":"Reference Center for Toxic Bullous Diseases and Severe Cutaneous Adverse Reactions Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05584.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30378-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14392"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2017.06.020"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19283"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32218-9"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ308"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.021"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.026"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw462"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00678.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13721"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13562"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.12.995"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm146"},{"key":"e_1_2_5_17_1","first-page":"331","article-title":"Cross\u2010reactivity and tolerability of cephalosporins in patients with cell\u2010mediated allergy to penicillins","volume":"24","author":"Buonomo A","year":"2014","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02058.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12299"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000318844"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.025"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13796"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02364.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12842"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065876"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.10.030"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12125"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450601.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12142"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.09.008"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh454"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.15986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.15986","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.15986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T19:49:33Z","timestamp":1694029773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.15986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,28]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/jdv.15986"],"URL":"https:\/\/doi.org\/10.1111\/jdv.15986","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,28]]},"assertion":[{"value":"2019-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}