{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:58:38Z","timestamp":1791406718770,"version":"4.3.3"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Light\u2010based therapies are one of the most effective and widely used strategies for removal of undesired hair, with a broadly favourable safety profile. However, subjects with pigmented skin are found to be more prone to laser\u2010related adverse events. While prolonged pulse\u2010width and longer treatment duration were proposed to minimize adverse events, the optimal treatment option among available phototherapy modalities \u2013 long\u2010pulsed (Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>), pulsed diode and alexandrite lasers as well as intense pulsed light (<jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>) \u2013 remains unclear, particularly for skin of colour. To determine superiority in terms of effectiveness and tolerability, we conducted a systematic review of literature on different types of in\u2010office laser and <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content> for hair removal in subjects with Fitzpatrick skin types <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>. The meta\u2010analysis was performed using Review Manager (RevMan) version 5.3 and included 12 eligible comparative trials (nine randomized controlled trials and three quasi\u2010randomized). In terms of hair count reduction, pooled effect estimates for long\u2010pulsed <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.26, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (0.1, 0.78)] and diode laser [standardized mean difference (<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>): \u22120.11, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (\u22120.62, 0.39)] were not statistically significant from those of <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>; in contrast, alexandrite laser was found to be superior to <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content> in reducing hair count [<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>: \u22121.7, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (\u22122.6, \u22120.78)]. In terms of adverse events, the pooled effect estimates favoured long\u2010pulsed Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser to <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content> with respect to postinflammatory hyperpigmentation [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.26, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: (0.1, 0.78)]. However, both pulsed diode and alexandrite lasers exhibited a comparable safety profile to <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>, despite higher pain scores with lasers. In conclusion, this systematic review suggests that treatment outcomes for different in\u2010office laser devices and <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content> in subjects with skin type <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> are broadly similar; nevertheless, we observed a trend towards greater hair reduction following laser therapy compared with <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jdv.15995","type":"journal-article","created":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T08:55:31Z","timestamp":1570352131000},"page":"948-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Lasers for reduction of unwanted hair in skin of colour: a systematic review and 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