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To date, there are few studies investigating the determinants of telangiectasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated lifestyle and physiological factors associated with facial telangiectasia in a large prospective Dutch cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Telangiectasia was quantified digitally from standardized facial photographs of 2842 North European participants (56.8% female, median age 66.9) from the Rotterdam Study, collected in 2010\u20132013. Effect estimates from multivariable linear regressions are presented as the percentage difference in the mean value of telangiectasia area per unit increase of a determinant (%\u0394) with corresponding 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant determinants were older age [1.7%\u0394 per year (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4, 2.0)], female sex [18.3%\u0394 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 13.2, 23.6)], smoking [current versus never 38.4%\u0394 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 30.3, 47.0); former versus never 11.6%\u0394 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 6.6, 16.9)], a high susceptibility to sunburn [10.2%\u0394 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 5.4, 15.3)] and light skin colour [pale versus white\u2010to\u2010olive 31.4%\u0394 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 19.7, 44.1]; white vs. white\u2010to\u2010olive 9.2%\u0394 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.8, 16.0)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large cohort study, we confirmed known and described new determinants of facial telangiectasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15996","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T15:01:49Z","timestamp":1570546909000},"page":"821-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Epidemiology and determinants of facial telangiectasia: a cross\u2010sectional study"],"prefix":"10.1111","volume":"34","author":[{"given":"S.","family":"Meki\u0107","sequence":"first","affiliation":[{"name":"Department of Dermatology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Hamer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Wigmann","sequence":"additional","affiliation":[{"name":"IUF \u2013 Leibniz Research Institute for Environmental Medicine D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.","family":"Gunn","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Colworth Science Park Sharnbrook UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kayser","sequence":"additional","affiliation":[{"name":"Department of Genetic Identification Erasmus MC University Medical Center Rotterdam Rotterdam The 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