{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:42:32Z","timestamp":1787100152887,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hidradenitis suppurativa (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) is a chronic, debilitating, dermatological disease that causes substantial psychosocial impediments with increased suicidal risk. Yet data on psychiatric comorbidity in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> have not been sufficiently elucidated in population\u2010based studies. The current study sought to investigate the association between <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> and schizophrenia, a major psychiatric disease, in a nationwide population\u2010based study in Israel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data mining was performed on the database of Clalit Health Services (<jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content>), the largest managed healthcare company in Israel. Patients diagnosed with <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4191) were examined and compared to age\u2010 and sex\u2010matched controls (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>20\u00a0941). The association between <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> and schizophrenia was assessed via multivariate binary logistic regression, adjusting for demographic factors and smoking status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis revealed a tenfold increase in the prevalence of schizophrenia in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> patients compared to controls (1.4% and 0.4%, respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In multivariate analysis, <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> was found to be associated with schizophrenia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.44, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.01\u20132.07, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hidradenitis suppurativa is associated with schizophrenia. Screening for severe mental illness during the assessment of patients with <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> is of great importance, as comorbid psychiatric disorders may affect treatment outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.15997","type":"journal-article","created":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T09:26:45Z","timestamp":1570354005000},"page":"574-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Hidradenitis suppurativa and schizophrenia: a nationwide cohort study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-9616","authenticated-orcid":false,"given":"D.","family":"Tzur Bitan","sequence":"first","affiliation":[{"name":"Department of Behavioral Sciences Ariel University Ariel Israel"},{"name":"Shalvata Mental Health Center Affiliated with the Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Berzin","sequence":"additional","affiliation":[{"name":"School of Medicine Ben\u2010Gurion University of the Negev Be'er Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-9982","authenticated-orcid":false,"given":"A.D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Chief Physician's Office Clalit Health Services Tel Aviv Israel"},{"name":"Siaal Research Center for Family Medicine and Primary Care Faculty of Health Sciences Ben\u2010Gurion University of the Negev Be'er Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j3208"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17123"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.911"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2010.07.003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1082"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350056"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.021"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.16691"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.14.2101"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00619.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.3.337"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16458-1"},{"key":"e_1_2_5_15_1","first-page":"92","article-title":"Assessment of premorbid function in first\u2010episode schizophrenia: modifications to the Premorbid Adjustment Scale","volume":"27","author":"Mastrigt S","year":"2002","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.55.090902.141950"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2006.00563.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(02)00014-X"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n1105"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.02.007"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2014.02.008"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14303"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12567"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.06.020"},{"key":"e_1_2_5_25_1","unstructured":"Ministry of Health (Il)[Internet].Annual report of healthcare\u2010providing companies for 2017. 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