{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:21:31Z","timestamp":1790680891935,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T00:00:00Z","timestamp":1570320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence and incidence of cutaneous squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content>) are increasing due to the ageing of the population and sun exposure. Advanced <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> forms (locally advanced and\/or locoregional metastatic and\/or distant metastatic) account for approximately 3% of <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> and can result in death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Analysis of the clinical characteristics and treatment outcomes in stage <jats:styled-content style=\"fixed-case\">IV cSCC<\/jats:styled-content> with unresectable locoregional extension and\/or the presence of metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was conducted at a single\u2010centre university hospital for stage <jats:styled-content style=\"fixed-case\">IV cSCC<\/jats:styled-content> patients followed between 1 January 2008 and 31 December 2015. Descriptive analyses (demographic, anatomo\u2010clinical characteristics, treatment sequences, response to treatment and survival analysis) were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 42 patients (median age\u00a0=\u00a075.5\u00a0years) with a diagnosis of stage <jats:styled-content style=\"fixed-case\">IV cSCC<\/jats:styled-content> who were treated with at least one line of chemotherapy and\/or cetuximab. At the time of diagnosis, 85.7% of the patients had locoregional extension (19% of locally advanced and 67% of locoregional metastatic) and 14.3% had distant metastatic disease. Regarding treatment, 40% and 36% of patients received no more than 1 and 2 systemic treatment lines, respectively. The 4\u2010year overall survival was 6%, and the median follow\u2010up was 18.6\u00a0months. The objective response rate was 55% after the first line of treatment with a median progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) of 6.18\u00a0months and 12% after the second line with a median <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> of 6.51\u00a0months. Grade 3 and 4 adverse events were observed for 33% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study confirms a very poor prognosis of stage <jats:styled-content style=\"fixed-case\">IV cSCC<\/jats:styled-content> and a poor response to conventional therapies, indicating that the stage <jats:styled-content style=\"fixed-case\">IV cSCC<\/jats:styled-content> patient population remains with unmet medical needs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16007","type":"journal-article","created":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T09:18:06Z","timestamp":1570353486000},"page":"1202-1209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Stage <scp>IV<\/scp> cutaneous squamous cell carcinoma: treatment outcomes in a series of 42 patients"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-6429","authenticated-orcid":false,"given":"M.","family":"Chapalain","sequence":"first","affiliation":[{"name":"Dermatology Department H\u00f4pital Saint\u2010Louis AP\u2010HP Paris France"},{"name":"Inserm Unit\u00e9 976 H\u00f4pital Saint\u2010Louis Paris France"},{"name":"Universit\u00e9 Paris\u2010Diderot, Sorbonne\u2010Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Baroudjian","sequence":"additional","affiliation":[{"name":"Dermatology Department H\u00f4pital Saint\u2010Louis AP\u2010HP Paris France"},{"name":"Inserm Unit\u00e9 976 H\u00f4pital Saint\u2010Louis Paris France"},{"name":"Universit\u00e9 Paris\u2010Diderot, Sorbonne\u2010Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dupont","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Diderot, Sorbonne\u2010Paris\u2010Cit\u00e9 Paris France"},{"name":"Department of Biostatistics H\u00f4pital Saint\u2010Louis AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lhote","sequence":"additional","affiliation":[{"name":"Dermatology Department H\u00f4pital Saint\u2010Louis AP\u2010HP Paris France"},{"name":"Inserm Unit\u00e9 976 H\u00f4pital Saint\u2010Louis Paris France"},{"name":"Universit\u00e9 Paris\u2010Diderot, Sorbonne\u2010Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Diderot, Sorbonne\u2010Paris\u2010Cit\u00e9 Paris France"},{"name":"Department of Biostatistics H\u00f4pital Saint\u2010Louis AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bagot","sequence":"additional","affiliation":[{"name":"Dermatology Department H\u00f4pital Saint\u2010Louis AP\u2010HP Paris France"},{"name":"Inserm Unit\u00e9 976 H\u00f4pital Saint\u2010Louis Paris France"},{"name":"Universit\u00e9 Paris\u2010Diderot, Sorbonne\u2010Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lebbe","sequence":"additional","affiliation":[{"name":"Dermatology Department H\u00f4pital Saint\u2010Louis AP\u2010HP Paris France"},{"name":"Inserm Unit\u00e9 976 H\u00f4pital Saint\u2010Louis Paris France"},{"name":"Universit\u00e9 Paris\u2010Diderot, Sorbonne\u2010Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9136-1244","authenticated-orcid":false,"given":"N.","family":"Basset\u2010Seguin","sequence":"additional","affiliation":[{"name":"Dermatology Department H\u00f4pital Saint\u2010Louis AP\u2010HP Paris France"},{"name":"Inserm Unit\u00e9 976 H\u00f4pital Saint\u2010Louis Paris France"},{"name":"Universit\u00e9 Paris\u2010Diderot, Sorbonne\u2010Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.11.037"},{"key":"e_1_2_5_3_1","unstructured":"Carcinome \u00e9pidermo\u00efde cutan\u00e9 \u2013 prise en charge diagnostique et th\u00e9rapeutique: recommandations argument\u00e9es\u2010Ref: RECOCEC09 | Institut National Du Cancer [Internet]. 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