{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:29:20Z","timestamp":1792621760926,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne fulminans (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) is a rare and severe form of inflammatory acne. It is characterized by a sudden worsening of acne with appearance of ulceronecrotic lesions, which can be associated with systemic signs. Its pathophysiology and the best therapeutic strategy are only partially known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our main objectives were to describe the clinical and biological profile of <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients and to determine whether there was a difference in <jats:italic>Cutibacterium acnes<\/jats:italic> phylotype in <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> compared to acne vulgaris. The secondary objective was to assess the efficacy of different therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective observational study was conducted in all patients followed for <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> in our department between 2008 and 2018. Bacteriological samples were taken from each patient to analyse <jats:italic>C.\u00a0acnes<\/jats:italic> phylotype distribution. The therapeutic response was assessed using the <jats:styled-content style=\"fixed-case\">ECLA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GEA<\/jats:styled-content> scales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen patients with a median age of 15\u00a0years were included (12 men, 80%). A family history of acne was found in 86.7% of patients. Nine patients (60%) had isotretinoin\u2010induced <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>. Only one patient (6.7%) showed systemic signs. The bacteriological culture was positive for <jats:italic>C.\u00a0acnes<\/jats:italic> in 80% of patients. The predominant phylotype was <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>1 in 60% of patients, corresponding to the predominant phylotype in acne vulgaris. Only 33.3% of patients were in remission after a first\u2010line treatment with systemic corticosteroids, alone or in combination. Seven patients were treated with biotherapy, including five successfully with secukinumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that there is no specific <jats:italic>C.\u00a0acnes<\/jats:italic> phylotype associated with <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>, raising the hypothesis that acute inflammation associated with <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> may be more related to an abnormal cutaneous innate immunity activation. The use of preventive strategies, the impact of combined treatments and an assessment of the role of biotherapies, especially anti\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, in <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> treatment remain to be more investigated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16064","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T22:04:25Z","timestamp":1573596265000},"page":"827-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Acne fulminans and <i>Cutibacterium acnes<\/i> phylotypes"],"prefix":"10.1111","volume":"34","author":[{"given":"S.","family":"Bocquet\u2010Tr\u00e9moureux","sequence":"first","affiliation":[{"name":"Department of Dermatology CHU Nantes Nantes 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