{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:07:55Z","timestamp":1776866875408,"version":"3.51.2"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Decreased number of T\u2010regulatory cells (Tregs) and\/or their loss of function potentially lead to uncontrolled immune\u2010mediated inflammatory responses. There are only few data available on Tregs in hidradenitis suppurativa (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) \u2013 a disease in which it has been suggested that host immune factors and an overactive immune system of the follicular epithelium play a pathogenetic role.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyse frequencies of Tregs subpopulations in blood of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> patients in comparison with a healthy control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; methods<\/jats:title><jats:p>Blood samples obtained from <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> patients and healthy controls were evaluated by flow cytometry and enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of natural Tregs among <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T lymphocytes were significantly reduced in the <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> group compared to the healthy controls. The proportion of activated Tregs, non\u2010suppressive Tregs and proliferating Tregs showed no significant difference when compared to controls. Regarding Tregs frequencies, there was no significant difference between the three Hurley stages. Serum concentrations of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u00df1 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A did not show significant differences between the <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> and control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reduction of natural Tregs observed in blood of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> patients could be the result of Tregs homing to sites of inflammatory hot spots in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> skin. Further studies are justified evaluating the role of circulating Tregs during the evolution of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> lesions and as a biomarker for treatment response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16071","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T09:41:56Z","timestamp":1573638116000},"page":"834-838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Frequency of circulating subpopulations of T\u2010regulatory cells in patients with hidradenitis suppurativa"],"prefix":"10.1111","volume":"34","author":[{"given":"S.","family":"Hessam","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Gambichler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"H\u00f6xtermann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Skrygan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sand","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Ruhr\u2010University Bochum Bochum Germany"},{"name":"Department of Plastic and Reconstructive Surgery St. Josef\u2010Hospital Essen\u2010Kupferdreh Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Garcovich","sequence":"additional","affiliation":[{"name":"Institute of Dermatology F. 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