{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:29:09Z","timestamp":1790126949391,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alitretinoin is a systemic retinoid licensed for use in adult patients suffering from chronic hand eczema recalcitrant to potent topical steroids. Experience with its use in childhood is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report on the efficacy and safety of alitretinoin treatment in a cohort of children and adolescents with chronic hand eczema (<jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content>) and other inflammatory skin diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective chart review of all consecutive patients under the age of 18\u00a0years treated with alitretinoin at our paediatric skin centre. Physician's Global Assessment (<jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>) was used as the primary outcome measure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen children (9 girls and 4 boys) were enrolled in this study. The median age at start of treatment with alitretinoin was 11.5\u00a0years (range 5.8\u201315.8\u00a0years). Nine children were diagnosed with <jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content>, two with severe atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>), and two with inherited ichthyosis [netherton syndrome (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>), autosomal recessive congenital ichthyosis (<jats:styled-content style=\"fixed-case\">ARCI<\/jats:styled-content>)]. Moderate to excellent response (<jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content> decrease of \u22651 point) was observed in 7 (78%) of the nine patients with <jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content>, one of the two patients with extensive <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and in the one patient with <jats:styled-content style=\"fixed-case\">ARCI<\/jats:styled-content>. In the remaining four subjects, no convincing effect was documented. Tolerability was overall very good. The most common adverse event was headache in 10 patients (77%) during the initiation of treatment, leading to interruption of therapy in one subject.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alitretinoin seems to be highly effective and safe for the treatment of paediatric <jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content> and should thus be considered in children with refractory disease under topical therapy. Larger studies are required to corroborate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16088","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T17:18:54Z","timestamp":1574183934000},"page":"1037-1042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Safe and effective use of alitretinoin in children with recalcitrant hand eczema and other dermatoses \u2013 a retrospective analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7725-8171","authenticated-orcid":false,"given":"I.","family":"Luchsinger","sequence":"first","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vogler","sequence":"additional","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Schwieger\u2010Briel","sequence":"additional","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6438-6550","authenticated-orcid":false,"given":"N.","family":"Kn\u00f6pfel","sequence":"additional","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"W\u00e4lchli","sequence":"additional","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Weibel","sequence":"additional","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children's Hospital Zurich Zurich Switzerland"},{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-3958","authenticated-orcid":false,"given":"M.","family":"Theiler","sequence":"additional","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children's Hospital Zurich Zurich Switzerland"},{"name":"Department of Dermatology University Hospital Zurich Zurich 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