{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:37:09Z","timestamp":1787971029060,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eczema herpeticum (<jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content>) is a disseminated viral infection of eczematous skin disease with the herpes simplex virus. Knowledge on clinical characteristics, risk factors and recurrent disease is limited. Our aim was to better define clinical characteristics and risk factors for <jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content> and especially for recurrent <jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of <jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content> cases assessed the history, clinical signs, prior treatment and laboratory results using a predefined questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 224 <jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content> cases from eight European centres were included. Extrinsic <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was identified as risk factor for <jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content>, and only one patient suffered from intrinsic <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Early onset of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was identified as risk factor for recurrent <jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content>. Pretreatment with topical steroids, systemic steroids, topical calcineurin inhibitors or plain emollients reflected standard therapy. Many patients showed <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> lesions without <jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content>, but skin without <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> lesions was never affected by herpetic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with clinically active, extrinsic <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> are at risk of <jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content>. Recurrent <jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content> is associated with confounders of severe atopic distortion and requires active <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> lesions for clinical manifestation. Recurrent eczema herpeticum mainly affects patients with early onset of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16090","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T21:08:32Z","timestamp":1573938512000},"page":"1074-1079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Recurrent eczema herpeticum \u2013 a retrospective European multicenter study evaluating the clinical characteristics of eczema herpeticum cases in atopic dermatitis patients"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-6026","authenticated-orcid":false,"given":"M.","family":"Seegr\u00e4ber","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Ludwig\u2010Maximilian\u2010University Munich 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