{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:53:15Z","timestamp":1785268395340,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Systemic sclerosis (SS<\/jats:styled-content>c) is a multisystemic disease with an extensive microvasculopathy. Previously, disturbances in plasma levels of angiotensin II<\/jats:styled-content> (Ang II<\/jats:styled-content>) and its antagonistic angiotensin\u2010(1\u20107) (Ang\u2010(1\u20107)) were found in patients with SS<\/jats:styled-content>c. Their significance in a pathogenesis of SS<\/jats:styled-content>c stays unclear due to discrepancies of earlier studies.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To evaluate a significance of disturbances in production pathway of angiotensins in a development of SS<\/jats:styled-content>c.<\/jats:p><\/jats:sec>Methods<\/jats:title>There were enrolled 27 patients with established SS<\/jats:styled-content>c, 23 subjects with very early SS<\/jats:styled-content>c and 23 healthy controls. The diagnosis of SS<\/jats:styled-content>c was established in patients who met EULAR<\/jats:styled-content>\/ACR<\/jats:styled-content> 2013 classification criteria. Very early SS<\/jats:styled-content>c described patients with Raynaud's phenomenon having SS<\/jats:styled-content>c\u2010specific antinuclear antibodies and SS<\/jats:styled-content>c\u2010like abnormalities in nailfold videocapillaroscopy. Patients were submitted to evaluation of internal organ involvement and blood sampling to assay plasma levels of angiotensin I, angiotensin II<\/jats:styled-content> and angiotensin\u2010(1\u20107) with ELISA<\/jats:styled-content> technique.<\/jats:p><\/jats:sec>Results<\/jats:title>Plasma level of angiotensin\u2010(1\u20107) was significantly reduced in both SS<\/jats:styled-content>c group (median\u00a0=\u00a047.2\u00a0pg\/mL; P<\/jats:italic>\u00a0<\u00a00.001) and ones with very early SS<\/jats:styled-content>c (median\u00a0=\u00a0102.7\u00a0pg\/mL; P<\/jats:italic>\u00a0=\u00a00.002) when compared to healthy controls (median\u00a0=\u00a0176.1\u00a0pg\/mL). A tendency to higher than in control group (median\u00a0=\u00a0214\u00a0pg\/mL) plasma level of angiotensin I was seen in SS<\/jats:styled-content>c group (median\u00a0=\u00a0392\u00a0pg\/mL; P<\/jats:italic>\u00a0=\u00a00.059). Differences in plasma level of angiotensin II<\/jats:styled-content> were insignificant between all study groups. Those disturbances produced unfavourable angiotensin\u2010(1\u20107)\/angiotensin II<\/jats:styled-content> (%) ratio in both groups of patients, which achieved statistical significance in subjects with established SS<\/jats:styled-content>c (P<\/jats:italic>\u00a0<\u00a00.001). Production pathway of angiotensins showed a dependence on a subtype of SS<\/jats:styled-content>c, immune profile and a presence of interstitial lung disease.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Production of angiotensin\u2010(1\u20107) was significantly reduced in both SS<\/jats:styled-content>c patients and those ones with very early SS<\/jats:styled-content>c, although a significant imbalance between angiotensin II<\/jats:styled-content> and angiotensin\u2010(1\u20107) occurred only in subjects with established disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16103","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T12:59:24Z","timestamp":1574254764000},"page":"558-564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Significance of the angiotensin I\/angiotensin II<\/scp>\/angiotensin\u2010(1\u20107) axis in the pathogenesis of systemic sclerosis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8388-4419","authenticated-orcid":false,"given":"B.","family":"Mizio\u0142ek","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine in Katowice Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-5984","authenticated-orcid":false,"given":"B.","family":"Bergler\u2010Czop","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine in Katowice Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kucharz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rheumatology and Clinical Immunology School of Medicine in Katowice Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kotyla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rheumatology and Clinical Immunology School of Medicine in Katowice Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kope\u0107\u2010M\u0119drek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rheumatology and Clinical Immunology School of Medicine in Katowice Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Widuchowska","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rheumatology and Clinical Immunology School of Medicine in Katowice Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5528-5264","authenticated-orcid":false,"given":"M.","family":"Sie\u0144czyk","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Division of Medicinal Chemistry and Microbiology Wroclaw University of Science and Technology Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Brzezi\u0144ska\u2010Wcis\u0142o","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine in Katowice Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37988"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(08)80054-6"},{"key":"e_1_2_6_4_1","first-page":"328","article-title":"Reduced angiotensin converting enzyme plasma activity in scleroderma. 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