{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:21:09Z","timestamp":1791343269936,"version":"4.3.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Organ transplant recipients (OTR) have a higher risk of actinic keratosis (AK) and keratinocyte carcinomas (KC). There are no clinical trials assessing the effectiveness of daylight photodynamic therapy (DPDT) to prevent new AK and KC in OTR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether repeated treatments of field cancerization with DPDT are effective in preventing new AK and KC in OTR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, intra\u2010subject controlled, evaluator\u2010blind, split\u2010face and\/or scalp trial, from April 2016 to October 2018. Participants were OTR older than 18\u00a0years, 1\u2010year posttransplant, with at least 5 AK on each hemi\u2010face\/hemi\u2010scalp. One side received six field treatments with DPDT: two sessions 15\u00a0days apart at baseline, two at 3\u00a0months and two at 9\u00a0months after baseline. Control side received lesion\u2010directed treatment with cryotherapy (double freeze\u2013thaw) at baseline, 3 and 9\u00a0months. Total number of lesions (AK and KC) at 21\u00a0months, number of new AK and KC at 3, 9, 15 and 21\u00a0months and treatment preferences were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 24 men included, 23 were analysed at 3\u00a0months; and 21, at 9, 15 and 21\u00a0months. Mean (SD) age was 69.8\u00a0years (9.2). The total number of lesions at 21\u00a0months was 4.7 (4.3) for DPDT and 5.8 (5.0) for control side; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.09. DPDT showed significantly lower means [SD] of new lesions compared to control side at 3\u00a0months (4.2 [3.4] vs. 6.8 [4.8]; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), 9\u00a0months (3.0 [3.3] vs. 4.3 [3.4]; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04) and 15\u00a0months (3.0 [4.6] vs. 4.8 [5.0]; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02), and non\u2010significant at 21\u00a0months (3.7 [3.5] vs. 5.0 [4.5]; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.06). Most participants preferred DPDT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DPDT showed potential effectiveness in preventing new AK and KC in OTR by consecutive treatments of field cancerization. The preference for DPDT could facilitate adherence to the long\u2010term treatment necessary in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16125","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:26:54Z","timestamp":1575282414000},"page":"1464-1470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Daylight photodynamic therapy for prevention of new actinic keratosis and keratinocyte carcinomas in organ transplants. 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