{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:06:53Z","timestamp":1787170013090,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Hidradenitis suppurativa (\n HS<\/jats:styled-content>\n ) is a chronic, inflammatory, skin condition associated with many comorbidities and often has a substantial impact on patients\u2019 lives.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To evaluate symptom burden and health\u2010related quality of life (\n HRQ<\/jats:styled-content>\n oL) at baseline in patients with\n HS<\/jats:styled-content>\n in an observational, real\u2010world, clinical setting using several tools including a validated\n HS<\/jats:styled-content>\n \u2010specific instrument.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study evaluated\n HRQ<\/jats:styled-content>\n oL data from the international\n UNITE HS<\/jats:styled-content>\n disease registry. Administration of patient\u2010reported outcome (\n PRO<\/jats:styled-content>\n ) instruments and collection of data were executed per local regulations. All data were assessed using descriptive statistical methods.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n PRO<\/jats:styled-content>\n data from 529 adults and 65 adolescents were evaluated. Most adults (64.5%) and adolescents (73.8%) were classified as Hurley Stage\n II<\/jats:styled-content>\n with substantial disease burden at baseline.\n HS<\/jats:styled-content>\n had a large effect (mean\n DLQI<\/jats:styled-content>\n \u00a0=\u00a012.6) and moderate effect (mean\n CDLQI<\/jats:styled-content>\n \u00a0=\u00a06.9) on the lives of adults and adolescents, respectively. Approximately 58% of adults and 41% of adolescents had anxiety scores beyond the normal range; 30% of adults and 16% of adolescents exhibited symptoms of depression. Based on\n HSSA<\/jats:styled-content>\n and\n HSIA<\/jats:styled-content>\n scores, approximately 30% of adults reported a substantial burden of multiple\n HS<\/jats:styled-content>\n clinical symptoms and more than 45% reported a significant emotional impact of\n HS<\/jats:styled-content>\n that adversely affected their intimate relationships. Only 60% of adults were employed and of those, 64% reported at least some degree of impairment while working because of\n HS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Based on\n PRO<\/jats:styled-content>\n s collected from patients enrolled in the\n UNITE<\/jats:styled-content>\n registry, a real\u2010world, clinical setting,\n HS<\/jats:styled-content>\n has a significant negative impact on the everyday lives of patients affected by this disease.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.16132","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T08:51:48Z","timestamp":1575449508000},"page":"1302-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Baseline patient\u2010reported outcomes from\n UNITE<\/scp>\n : an observational, international, multicentre registry to evaluate hidradenitis suppurativa in clinical practice"],"prefix":"10.1111","volume":"34","author":[{"given":"A.B.","family":"Kimball","sequence":"first","affiliation":[{"name":"Harvard Medical School and Beth Israel Deaconess Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Crowley","sequence":"additional","affiliation":[{"name":"Bakersfield Dermatology Bakersfield CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Papp","sequence":"additional","affiliation":[{"name":"Clinical Research and Probity Medical Research Waterloo ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Calimlim","sequence":"additional","affiliation":[{"name":"AbbVie Inc North Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Duan","sequence":"additional","affiliation":[{"name":"AbbVie Inc North Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.B.","family":"Fleischer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sobell","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tufts University School of Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.047"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1014163"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.911"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6569"},{"key":"e_1_2_7_6_1","first-page":"1547","article-title":"Hidradenitis suppurativa: a treatment challenge","volume":"72","author":"Shah N","year":"2005","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1082"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0866"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.2018.042"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8018192"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.053"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1395806"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04468.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.021"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.061"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0105-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-29"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1341614"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199304050-00006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb16953.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1265"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16078"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12067_suppl"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13122"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.07.027"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15353"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08236.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000104263"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.16132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.16132","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T12:23:45Z","timestamp":1693743825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.16132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/jdv.16132"],"URL":"https:\/\/doi.org\/10.1111\/jdv.16132","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"2019-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}