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Original studies on the use of SCORTEN were eligible. The standardized mortality ratio (SMR), defined as the quotient between the number of deaths observed and the number expected following SCORTEN, was taken as the measurement of analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four papers were part of the main meta\u2010analysis carried out in the study. A pooled log(SMR) of \u22120.0889 (95% CI: \u22120.2023 to 0.0245) was obtained, suggesting a reasonable behaviour of SCORTEN as a predictor of mortality. The possible influence of several factors in the accuracy of SCORTEN was studied by means of meta\u2010regression models. Multivariate meta\u2010regression allowed finding that the mean age of the patients and the ending year of the study are the only factors that significantly influence SCORTEN predictions. The mean age of the group of patients was associated with a significant increase in the observed\/expected ratio, whereas a progressive reduction in the observed\/expected ratio can be appreciated over the years. Finally, an underestimation of mortality was found for SCORTEN values of 3 or less and the opposite for those above 3 (SCORTEN range: 0\u20137).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The rarity of the disease and the heterogeneity of the studies included are major limitations. Despite the overall remarkable accuracy displayed by SCORTEN, the influence of several factors, as comorbidities (e.g. renal impairment), involved body surface area and patient's age, seem of enough relevance to consider a redefinition of the scale.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16137","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T11:33:46Z","timestamp":1575372826000},"page":"2066-2077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Accuracy of SCORTEN to predict the prognosis of Stevens\u2010Johnson syndrome\/toxic epidermal necrolysis: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-5360","authenticated-orcid":false,"given":"I.","family":"Torres\u2010Navarro","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Universitario y Polit\u00e9cnico la Fe Val\u00e8ncia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7976-3534","authenticated-orcid":false,"given":"\u00c1.","family":"Briz\u2010Red\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Statistics and Operations Research Universitat de Val\u00e8ncia Val\u00e8ncia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6153-8192","authenticated-orcid":false,"given":"R.","family":"Botella\u2010Estrada","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario y Polit\u00e9cnico la Fe Val\u00e8ncia Spain"},{"name":"Department of Medicine Universitat de Val\u00e8ncia Val\u00e8ncia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670250043005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311906"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00061.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700068"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31815f3865"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31820aafbc"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.510"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04502.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2017.09.015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203642"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000216532.71360.9B"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irx016"},{"key":"e_1_2_6_15_1","first-page":"e35","article-title":"Are multimorbidities underestimated in scoring systems of Stevens\u2010Johnson syndrome and toxic epidermal necrolysis like in SCORTEN?","volume":"12","author":"Wild T","year":"2012","journal-title":"Eplasty"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.03.023"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13505"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2016.04.018"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083138"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-1376"},{"key":"e_1_2_6_21_1","unstructured":"HigginsJ GreenS.Cochrane Handbook for Systematic Reviews of Interventions. 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