{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T03:11:54Z","timestamp":1771902714097,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Imiquimod 3.75% cream (Zyclara<jats:sup>\u00ae<\/jats:sup> Meda, Stockholm, Sweden) is a new field\u2010directed therapy for actinic keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim is to evaluate efficacy and the morphologic dynamic changes induced by this treatment by means of dermatoscopy and reflectance confocal microscopy (<jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>) of imiquimod 3.75% cream for the treatment of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s of the face or scalp and to evaluate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two patients were treated with Imiquimod 3.75% cream. Demographic parameters, <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FAS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AKASI<\/jats:styled-content> scores and side\u2010effects were collected. <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> and dermatoscopy on one target <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s were performed at each visit. We collected images at baseline (T0), after 1\u00a0week from the end of the first 2\u2010week cycle (T1), after 1\u00a0week from the end of the entire treatment (T2) and 2\u00a0months after the end of treatment (T3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One target representative <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> in the selected area of treatment of each patient was analysed. All dermoscopic and confocal parameters were reduced 2\u00a0months after the end of the therapy (T3) with a substantial reduction of <jats:styled-content style=\"fixed-case\">AKASI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FAS<\/jats:styled-content> scores, and 17 cases (54.8%) were completely solved. Confocal microscopic analysis showed a reduction of keratinocytes disarray in 77.4% of cases; none showed crusts and parakeratosis. Inflammation was considerably decreased and was observed only in 12.9% of patients at the last visit. This improvement was not assessed on dermatoscopy because of inflammation and background erythema, which adversely influenced the assessments. <jats:styled-content style=\"fixed-case\">LSR<\/jats:styled-content>s were observed in almost all the patients during treatment being more severe after the first cycle of treatment (T1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Imiquimod 3.75% cream is effective in treating clinical and subclinical <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s with an easy management of side\u2010effects. Dermatoscopy and mostly <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> allow non\u2010invasive monitoring of treatment response <jats:italic>in\u00a0vivo<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16143","type":"journal-article","created":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T04:45:20Z","timestamp":1576385120000},"page":"1471-1477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Digital follow\u2010up by means of dermatoscopy and reflectance confocal microscopy of actinic keratosis treated with Imiquimod 3.75% cream"],"prefix":"10.1111","volume":"34","author":[{"given":"E.","family":"Benati","sequence":"first","affiliation":[{"name":"Centro Oncologico ad Alta Tecnologia Diagnostica Azienda Unit\u00e0 Sanitaria Locale \u2013 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Longhitano","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Modena and Reggio Emilia Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-879X","authenticated-orcid":false,"given":"R.","family":"Pampena","sequence":"additional","affiliation":[{"name":"Centro Oncologico ad Alta Tecnologia Diagnostica Azienda Unit\u00e0 Sanitaria Locale \u2013 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mirra","sequence":"additional","affiliation":[{"name":"Centro Oncologico ad Alta Tecnologia Diagnostica Azienda Unit\u00e0 Sanitaria Locale \u2013 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Raucci","sequence":"additional","affiliation":[{"name":"Centro Oncologico ad Alta Tecnologia Diagnostica Azienda Unit\u00e0 Sanitaria Locale \u2013 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Modena and Reggio Emilia Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-3896","authenticated-orcid":false,"given":"C.","family":"Longo","sequence":"additional","affiliation":[{"name":"Centro Oncologico ad Alta Tecnologia Diagnostica Azienda Unit\u00e0 Sanitaria Locale \u2013 IRCCS di Reggio Emilia Reggio Emilia Italy"},{"name":"Dermatology Department University of Modena and Reggio Emilia Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103339"},{"issue":"1","key":"e_1_2_5_3_1","first-page":"3","article-title":"Actinic keratosis and field cancerisation","volume":"21","author":"Stockfleth E","year":"2011","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000254893"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11202.x"},{"key":"e_1_2_5_6_1","first-page":"227","article-title":"Zyclara (imiquimod) cream, 3.75%","volume":"8","author":"Gupta AK","year":"2010","journal-title":"Skinmed"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2014.2265"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.07.004"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/135916"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12829"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.02.011"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13215"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000254893"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2984"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0094-9"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14803"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12613"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12714"},{"key":"e_1_2_5_19_1","first-page":"28","article-title":"Imiquimod 2.5% and 3.75% cream for the treatment of photodamage: a meta\u2010analysis of efficacy and tolerability in 969 randomized patients","volume":"11","author":"Rosso J","year":"2018","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14267"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2710"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2016.05.008"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13260"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.16143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T18:28:26Z","timestamp":1693938506000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.16143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,22]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/jdv.16143"],"URL":"https:\/\/doi.org\/10.1111\/jdv.16143","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,22]]},"assertion":[{"value":"2019-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}