{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:49:22Z","timestamp":1791362962374,"version":"4.3.1"},"reference-count":73,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The large unmet need of hidradenitis suppurativa\/acne inversa (\n HS<\/jats:styled-content>\n ) therapy requires the elucidation of disease\u2010driving mechanisms and tissue targeting.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n Robust characterization of the underlying\n HS<\/jats:styled-content>\n mechanisms and detection of the involved skin compartments.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Hidradenitis suppurativa\/acne inversa molecular taxonomy and key signalling pathways were studied by whole transcriptome profiling. Dysregulated genes were detected by comparing lesional and non\u2010lesional skin obtained from female\n HS<\/jats:styled-content>\n patients and matched healthy controls using the Agilent array platform. The differential gene expression was confirmed by quantitative real\u2010time\n PCR<\/jats:styled-content>\n and targeted protein characterization via immunohistochemistry in another set of female patients.\n HS<\/jats:styled-content>\n \u2010involved skin compartments were also recognized by immunohistochemistry.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Alterations to key regulatory pathways involving glucocorticoid receptor, atherosclerosis,\n HIF<\/jats:styled-content>\n 1\u03b1 and\n IL<\/jats:styled-content>\n 17A signalling as well as inhibition of matrix metalloproteases were detected. From a functional standpoint, cellular assembly, maintenance and movement, haematological system development and function, immune cell trafficking and antimicrobial response were key processes probably being affected in\n HS<\/jats:styled-content>\n . Sixteen genes were found to characterize\n HS<\/jats:styled-content>\n from a molecular standpoint (\n \n DEFB<\/jats:styled-content>\n 4\n <\/jats:italic>\n ,\n \n MMP<\/jats:styled-content>\n 1\n <\/jats:italic>\n ,\n \n GJB<\/jats:styled-content>\n 2\n <\/jats:italic>\n ,\n \n PI<\/jats:styled-content>\n 3\n <\/jats:italic>\n ,\n \n KRT<\/jats:styled-content>\n 16\n <\/jats:italic>\n ,\n \n MMP<\/jats:styled-content>\n 9\n <\/jats:italic>\n ,\n \n SERPINB<\/jats:styled-content>\n 4\n <\/jats:italic>\n ,\n \n SERPINB<\/jats:styled-content>\n 3\n <\/jats:italic>\n ,\n \n SPRR<\/jats:styled-content>\n 3\n <\/jats:italic>\n ,\n S100A8<\/jats:italic>\n ,\n S100A9<\/jats:italic>\n ,\n S100A12<\/jats:italic>\n ,\n S100A7A (15)<\/jats:italic>\n ,\n \n KRT<\/jats:styled-content>\n 6A\n <\/jats:italic>\n ,\n \n TCN<\/jats:styled-content>\n 1\n <\/jats:italic>\n ,\n \n TMPRSS<\/jats:styled-content>\n 11D\n <\/jats:italic>\n ). Among the proteins strongly expressed in\n HS<\/jats:styled-content>\n , calgranulin\u2010A, calgranulin\u2010B and serpin\u2010B4 were detected in the hair root sheath, koebnerisin and connexin\u201032 in stratum granulosum, transcobalamin\u20101 in stratum spinosum\/hair root sheath, small prolin\u2010rich protein\u20103 in apocrine sweat gland ducts\/sebaceous glands\u2010ducts and matrix metallopeptidase\u20109 in resident monocytes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our findings highlight a panel of immune\u2010related drivers in\n HS<\/jats:styled-content>\n , which influence innate immunity and cell differentiation in follicular and epidermal keratinocytes as well as skin glands.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.16147","type":"journal-article","created":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T01:03:03Z","timestamp":1576371783000},"page":"846-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Alterations in innate immunity and epithelial cell differentiation are the molecular pillars of hidradenitis suppurativa"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-2608","authenticated-orcid":false,"given":"C.C.","family":"Zouboulis","sequence":"first","affiliation":[{"name":"Departments of Dermatology, Venereology, Allergology and Immunology Dessau Medical Center Brandenburg Medical School Theodor Fontane Dessau Germany"},{"name":"European Hidradenitis Suppurativa Foundation e.V. 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