{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:29:13Z","timestamp":1790504953649,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013995","name":"Sanofi Genzyme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Atopic eczema (\n AE<\/jats:styled-content>\n ) may be associated with several mental health problems. In Germany, existing data from selected patient cohorts may lead to misestimation of the problem.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n We aimed to cross\u2010sectionally determine associations of AE with depression, anxiety, quality of life (QoL) and social interactions in subjects from the population\u2010based LIFE\u2010Adult\u2010Study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Subjects underwent standardized interviews (medical history) and answered standardized questionnaires [Centre of Epidemiologic studies\u2010Depression scale (\n CES<\/jats:styled-content>\n \u2010D), Generalized Anxiety Disorder (\n GAD<\/jats:styled-content>\n \u20107), Lubben Social Network Scale (\n LSNS<\/jats:styled-content>\n ), Short Form Health Survey (\n SF<\/jats:styled-content>\n \u20108)]. We compared data from subjects with\n AE<\/jats:styled-content>\n with those from subjects with selected other chronic\/disabling diseases (cardiovascular, diabetes, cancer) and adjusted for selected sociodemographic parameters. Multivariate binary logistic regression was used for categorical variables, linear regression for continuous variables.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Out of 9104 adults included (57% female, median age 54\u00a0years), 372 (4.1%) had a history of\n AE<\/jats:styled-content>\n . Compared with controls, subjects with\n AE<\/jats:styled-content>\n showed higher scores for depressive symptoms (9.3% vs. 6.3%;\n P<\/jats:italic>\n \u00a0<\u00a00.001) and anxiety (8.4% vs. 5.6%,\n P<\/jats:italic>\n \u00a0<\u00a00.001). Odds ratio (\n OR<\/jats:styled-content>\n ) was 1.5 [\n CI<\/jats:styled-content>\n 1.0; 2.3] (\n P<\/jats:italic>\n \u00a0=\u00a00.031) for depression, which was comparable to\n OR<\/jats:styled-content>\n in patients with a history of cancer (\n OR<\/jats:styled-content>\n 1.6 [1\u20132.3],\n P<\/jats:italic>\n \u00a0=\u00a00.001.\n OR<\/jats:styled-content>\n for anxiety in\n AE<\/jats:styled-content>\n was 1.5 [1.0; 2.2],\n P<\/jats:italic>\n \u00a0<\u00a00.049, which was slightly higher than in diabetes mellitus (\n OR<\/jats:styled-content>\n 1.2) and stroke (\n OR<\/jats:styled-content>\n 1.4). Other than in diabetes and\/or stroke, we did not find a significant association between\n AE<\/jats:styled-content>\n and social isolation. QoL scores were lower in\n AE<\/jats:styled-content>\n than in controls (mean 46.9 vs. 48.0,\n P<\/jats:italic>\n \u00a0<\u00a00.001 for physical and 50.6 vs. 52.5,\n P<\/jats:italic>\n \u00a0<\u00a00.001 for mental components).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Subjects with\n AE<\/jats:styled-content>\n showed higher values for depression and anxiety as well as lower QoL scores compared to controls. With regard to depression, odds in\n AE<\/jats:styled-content>\n and cancer were hardly different. Medical care of\n AE<\/jats:styled-content>\n patients should therefore include mental health evaluation and treatment if indicated.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.16148","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T23:29:15Z","timestamp":1576366155000},"page":"810-816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Depression, anxiety and quality of life in subjects with atopic eczema in a population\u2010based cross\u2010sectional study in Germany"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9642-4742","authenticated-orcid":false,"given":"R.","family":"Treudler","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology UMC Leipzig Leipzig Germany"},{"name":"LIFE \u2010 Leipzig Research Centre for Civilization Diseases University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zeynalova","sequence":"additional","affiliation":[{"name":"LIFE \u2010 Leipzig Research Centre for Civilization Diseases University of Leipzig Leipzig Germany"},{"name":"Institute for Medical Informatics, Statistics and Epidemiology (IMISE) University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.G.","family":"Riedel\u2010Heller","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine, Occupational Medicine, and Public Health (ISAP) University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.E.","family":"Zuelke","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine, Occupational Medicine, and Public Health (ISAP) University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Roehr","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine, Occupational Medicine, and Public Health (ISAP) University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hinz","sequence":"additional","affiliation":[{"name":"LIFE \u2010 Leipzig Research Centre for Civilization Diseases University of Leipzig Leipzig Germany"},{"name":"Department of Medical Psychology and Medical Sociology University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Glaesmer","sequence":"additional","affiliation":[{"name":"LIFE \u2010 Leipzig Research Centre for Civilization Diseases University of Leipzig Leipzig Germany"},{"name":"Department of Medical Psychology and Medical Sociology University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kage","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology UMC Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Loeffler","sequence":"additional","affiliation":[{"name":"LIFE \u2010 Leipzig Research Centre for Civilization Diseases University of Leipzig Leipzig Germany"},{"name":"Institute for Medical Informatics, Statistics and Epidemiology (IMISE) University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology UMC Leipzig Leipzig Germany"},{"name":"LIFE \u2010 Leipzig Research Centre for Civilization Diseases University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15634"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14495"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.11.030"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.06.029"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13360"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20556"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.12.019"},{"key":"e_1_2_7_9_1","first-page":"202","article-title":"Comorbidity of diabetes mellitus and depression in the general population in Germany","volume":"42","author":"Maske UE","year":"2015","journal-title":"Psychiatr Prax"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107816"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.08.022"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.08.063"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10799.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.03.017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.47102\/annals-acadmedsg.V45N10p451","article-title":"Anxiety and depression in patients with atopic dermatitis in a Southeast Asian Tertiary Dermatological Centre","volume":"45","author":"Lim VZ","year":"2016","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.08.028"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.337"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.03.037"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.11.029"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000949"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.04.019"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.02.025"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.06.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-1160-7"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2797"},{"key":"e_1_2_7_26_1","article-title":"Atopic dermatitis and psychosocial comorbidities","author":"Kage P","year":"2020","journal-title":"J Deutsch Dermatol Ges"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3257"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13231"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.530"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13813"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-018-4261-z"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1634"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2741"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-1983-z"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058067"},{"key":"e_1_2_7_36_1","first-page":"148","article-title":"The prevalence of current depressive symptoms in an urban adult population","volume":"44","author":"Luck T","year":"2017","journal-title":"Psychiatr Prax"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.04.073"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.12.012"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e318160d093"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/46.4.503"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-005-1168-5"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1026\/0012-1924\/a000068"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14888"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)67964-6"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17330"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17683"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182145"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2017.05.014"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1374"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13326"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2017.38.4005"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.07.006"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490002"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.4082\/kjfm.2015.36.6.261"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18252"},{"key":"e_1_2_7_56_1","first-page":"1","article-title":"Dupilumab improves patient\u2010reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health\u2010related quality of life in moderate\u2010to\u2010severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2","author":"Cork MJ","year":"2019","journal-title":"J Dermatolog Treat"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00318"},{"key":"e_1_2_7_58_1","first-page":"732","article-title":"Serotonergic markers in atopic dermatitis","volume":"96","author":"Rasul A","year":"2016","journal-title":"Acta Derm Venereol"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.16148","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T15:48:47Z","timestamp":1694015327000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.16148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/jdv.16148"],"URL":"https:\/\/doi.org\/10.1111\/jdv.16148","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,20]]},"assertion":[{"value":"2019-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}