{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:32:18Z","timestamp":1781307138274,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,12]],"date-time":"2020-01-12T00:00:00Z","timestamp":1578787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent data demonstrated that an altered basal membrane, activated melanocytes and secreted factors from keratinocytes but also fibroblasts and endothelial cells are involved in the pathophysiology of melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy and tolerability on melasma of a new topical skin\u2010lightening cosmetic product combination (<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content>) targeting several factors identified to be involved in melasma pathogenesis compared to 4% hydroquinone (<jats:styled-content style=\"fixed-case\">HQ<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three women with melasma were enrolled in a 12\u2010week double\u2010blind, randomized, parallel\u2010group trial and treated with <jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> or 4% <jats:styled-content style=\"fixed-case\">HQ<\/jats:styled-content> cream. Efficacy was evaluated with the modified Melasma Area Severity Index (mMASI) score and colorimetric change. Cutaneous tolerability and patient satisfaction were also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">mMASI<\/jats:styled-content> score decreased for both products from baseline and over the study period. At week 12, 90% of the subjects who received the combination products had an improvement in pigmentation vs. 79% with <jats:styled-content style=\"fixed-case\">HQ<\/jats:styled-content>. Similarly, both products significantly increased Individual Typological Angle parameters. For both measures, no statistically significant difference was observed between <jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HQ<\/jats:styled-content> in terms of change from baseline. <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> was very well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cosmetic product combination is as effective as <jats:styled-content style=\"fixed-case\">HQ<\/jats:styled-content> in the management of facial dyspigmentation and represents a safe alternative.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16150","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T05:49:57Z","timestamp":1576820997000},"page":"897-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy and tolerability on melasma of a topical cosmetic product acting on melanocytes, fibroblasts and endothelial cells: a randomized comparative trial against 4% hydroquinone"],"prefix":"10.1111","volume":"34","author":[{"given":"E.","family":"Bronzina","sequence":"first","affiliation":[{"name":"ISISPHARMA Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Clement","sequence":"additional","affiliation":[{"name":"ISISPHARMA Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Marie","sequence":"additional","affiliation":[{"name":"Insight Research \u2013 Dermscan Group Quatre Bornes Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.T.","family":"Fook Chong","sequence":"additional","affiliation":[{"name":"Insight Research \u2013 Dermscan Group Quatre Bornes Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Faure","sequence":"additional","affiliation":[{"name":"DEWAVRIN GROUP Wasquehal France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-6570","authenticated-orcid":false,"given":"T.","family":"Passeron","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universit\u00e9 C\u00f4te d'Azur CHU Nice Nice France"},{"name":"INSERM U1065 C3M Universit\u00e9 C\u00f4te d'Azur Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12290"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12684"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.95"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12273"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.023"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.07.833"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70071-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181ef2d45"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-0963.2001.04556.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.01.009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.01057.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.270"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.365"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.332"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05305.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2005.40202.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.051"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12291"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0194-1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-014-0064-z"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700629"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9475com"},{"key":"e_1_2_6_24_1","first-page":"28","article-title":"Are natural ingredients effective in the management of hyperpigmentation? 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