{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:00:49Z","timestamp":1791295249618,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009754","name":"Galderma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n We know the efficacy of daylight phototherapy dynamic (\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n ) in the treatment of actinic keratosis (\n AK<\/jats:styled-content>\n ). But the almost studies have compared daylight with red light using methyl aminolevulinate cream and not with blue light.\n PDT<\/jats:styled-content>\n with blue light is another conventional\n PDT<\/jats:styled-content>\n that is effective in the treatment of\n AK<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n The aim of this study is to assess the efficacy and the safety of\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n vs.\n PDT<\/jats:styled-content>\n in blue light in the treatment of\n AK<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This randomized, controlled, intra\u2010individual efficacy and safety study enrolled 26 subjects.\n AK<\/jats:styled-content>\n s on the face\/scalp were treated once, with\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n on one side and c\u2010\n PDT<\/jats:styled-content>\n on the contralateral side. Primary endpoints for\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n at week 12 were efficacy with clearance of\n AK<\/jats:styled-content>\n s and safety with assessment of pain. Lesions with complete response 12\u00a0weeks after one treatment session were followed until week 24.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n More than 1000\n AK<\/jats:styled-content>\n were studied. At week 12, the raw number of disappeared\n AK<\/jats:styled-content>\n lesions at 3\u2010month follow\u2010up was 19.6 (\u00b16.0) for\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n and 20.0 (\u00b16.9) for c\u2010\n PDT<\/jats:styled-content>\n with\n P<\/jats:italic>\n \u00a0=\u00a00.8460 (90.5% vs. 94.2% of\n AK<\/jats:styled-content>\n disappearance, respectively). The response was maintained at 6\u00a0months (90.0% and 94.6% of\n AK<\/jats:styled-content>\n reduction, respectively).\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n was nearly painless than c\u2010\n PDT<\/jats:styled-content>\n with light blue: 1.2 vs. 5.1, respectively (\n P<\/jats:italic>\n \u00a0<\u00a00.0001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Daylight\u2010\n PDT<\/jats:styled-content>\n seems as effective as c\u2010\n PDT<\/jats:styled-content>\n with light blue and\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n is less painful. The response of\n DL<\/jats:styled-content>\n \u2010\n PDT<\/jats:styled-content>\n was sustainable until 6\u00a0months.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.16208","type":"journal-article","created":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T04:30:10Z","timestamp":1579408210000},"page":"1730-1735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Daylight photodynamic therapy with methyl aminolevulinate cream is as effective as conventional photodynamic therapy with blue light in the treatment of actinic keratosis: a controlled randomized intra\u2010individual study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-5203","authenticated-orcid":false,"given":"S.","family":"Assikar","sequence":"first","affiliation":[{"name":"Department of Dermatology CHU Dupuytren Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Labrunie","sequence":"additional","affiliation":[{"name":"Centre d'Epid\u00e9miologie de BIostatistique et de MEthodologie de la Recherche (CEBIMER) CHU Dupuytren Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kerob","sequence":"additional","affiliation":[{"name":"Galderma International Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Couraud","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Dupuytren Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"B\u00e9dane","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Dupuytren Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08450.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13138"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13228"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11200.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12974"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353775"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.20.5.058001"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2011.09.004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00611.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10209.x"},{"key":"e_1_2_5_12_1","first-page":"154","article-title":"Daylight 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