{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:46:33Z","timestamp":1763642793826,"version":"3.40.5"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical studies on psoriasis in adolescents have mainly been performed in patients with severe psoriasis. Population\u2010based studies of clinical characteristics and risk factors for later cardiovascular and metabolic disease in children and adolescents are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the clinical characteristics of adolescents with psoriasis nested in a general population cohort. Furthermore, to investigate cardiovascular and metabolic risk factors in the adolescents with psoriasis compared to parentally predisposed and non\u2010predisposed adolescents without psoriasis from the same birth cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified adolescents with and without psoriasis using a nationwide general population birth cohort in Denmark. A clinical examination included skin inspection and scoring of psoriasis severity, completion of a questionnaire on psoriasis and comorbidities, physical measurements, and blood sampling. Participants also completed self\u2010administered questionnaires on quality of life and mental health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 81 adolescents with psoriasis and 234 controls (110 with genetic predisposition for psoriasis and 124 without predisposition). Median age was 15.6 (13.5\u201318.5) years, and in those with active psoriasis, median Psoriasis Area and Severity Index score was 1.2 (0.1\u201311.4). The scalp was the most common site of psoriasis, both at debut and at time of examination. Diaper rash in infancy was more frequent in the psoriasis group. No significant differences regarding quality of life, anxiety and depression were found. More adolescents with psoriasis were obese (8.6% vs. 1.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008), and physical measures of abdominal obesity were also significantly higher. HbA1c was significantly higher (31.55 vs. 30.81\u00a0mmol\/mol, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.048), while no differences were found for blood pressure, lipids or high\u2010sensitivity C\u2010reactive protein. In a subgroup analysis, this was evident in the non\u2010predisposed psoriasis\u2010free controls only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, adolescents with psoriasis from this general population had mild disease. Still, early markers of cardiovascular and metabolic disease were elevated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16229","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T05:01:03Z","timestamp":1580187663000},"page":"1516-1523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical characteristics including cardiovascular and metabolic risk factors in adolescents with psoriasis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0082-116X","authenticated-orcid":false,"given":"C.","family":"Blegvad","sequence":"first","affiliation":[{"name":"Copenhagen Research Group for Inflammatory Skin (CORGIS) Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"},{"name":"Section\u00a0of Epidemiology Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.\u2010M.","family":"Nybo Andersen","sequence":"additional","affiliation":[{"name":"Section\u00a0of Epidemiology Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Groot","sequence":"additional","affiliation":[{"name":"Copenhagen Research Group for Inflammatory Skin (CORGIS) Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"},{"name":"Section\u00a0of Epidemiology Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Copenhagen Research Group for Inflammatory Skin (CORGIS) Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Barker","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-9680","authenticated-orcid":false,"given":"L.","family":"Skov","sequence":"additional","affiliation":[{"name":"Copenhagen Research Group for Inflammatory Skin (CORGIS) Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12375"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.35"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13854"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2672"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2600"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.09.014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01746.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16104"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15213"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17994"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.14.1735"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0770"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.5417"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.034"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09593.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03801.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12072"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13507"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.3432"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.11.935"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2014.2291"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2816"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01281.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12491"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.03.006"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.1078"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1607"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12225"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.385"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12218"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.018003188.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-010-0213-0"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1986"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01452.x"},{"key":"e_1_2_6_36_1","first-page":"171","article-title":"Clinico\u2010epidemiological profile, including body mass index of Malaysian children with psoriasis","volume":"71","author":"Choon SE","year":"2016","journal-title":"Med J Malaysia"},{"key":"e_1_2_6_37_1","first-page":"e235","article-title":"Retrospective study of childhood psoriasis \u2010 psoriasis gene to clinic, 8th International Congress. The Queen Elizabeth II Conference Centre, London, U.K., 30th November \u2010 2nd December 2017","volume":"177","author":"Zorko MS","year":"2017","journal-title":"Br J Dermatol"},{"key":"e_1_2_6_38_1","first-page":"e235","article-title":"Psoriasis in children: a single\u2010centre analysis \u2010 psoriasis gene to clinic, 8th International Congress. The Queen Elizabeth II Conference Centre, London, U.K., 30th November \u2010 2nd December 2017","volume":"177","author":"Heppt F","year":"2017","journal-title":"Br J Dermatol"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/14034948010290040201"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031448"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00309-8"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb16953.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.043497"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70188-0"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12205"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-002-0321-3"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.141"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120470"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14507"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01408.x"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07507_supp.x"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602656"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9448-2"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000220549.14177.60"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.16229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.16229","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T18:29:01Z","timestamp":1693938541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.16229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,19]]},"references-count":55,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/jdv.16229"],"URL":"https:\/\/doi.org\/10.1111\/jdv.16229","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"type":"print","value":"0926-9959"},{"type":"electronic","value":"1468-3083"}],"subject":[],"published":{"date-parts":[[2020,2,19]]},"assertion":[{"value":"2019-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}