{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:39:20Z","timestamp":1792179560378,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few large studies have assessed spironolactone treatment of adult female acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the role of spironolactone in the treatment of adult female acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective case series assessing the efficacy of spironolactone treatment of a cohort of women evaluated at Mayo Clinic in Rochester, Minnesota, from 2007 through 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 395 patients (median age, 32\u00a0years) received a median spironolactone dose of 100\u00a0mg daily. Approximately two\u2010thirds of patients (66.1%) had a complete response; 85.1% had a complete response or a partial response greater than 50%. Median times to initial response and maximum response were 3 and 5\u00a0months. Efficacy was observed across all severity subtypes of acne, including those with papulopustular and nodulocystic acne. Patients received long\u2010term treatment with spironolactone (median duration, 13\u00a0months) and had few adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Spironolactone is a safe and effective treatment of acne for women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16302","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T16:10:12Z","timestamp":1582215012000},"page":"2106-2110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Treatment of acne with spironolactone: a retrospective review of 395 adult patients at Mayo Clinic, 2007\u20132017"],"prefix":"10.1111","volume":"34","author":[{"given":"E.E.","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN 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Valinotti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.F.","family":"Sciallis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.R.","family":"Torgerson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.","family":"Wetter","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN 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