{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:00:52Z","timestamp":1788487252545,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mucosal melanoma is a rare malignancy which represents approximately 1% of all melanomas. It is shown that mucosal melanomas have a different biology and less favourable prognosis than its cutaneous counterpart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Predictive and prognostic factors of survival for mucosal melanoma have not yet been elucidated. The aim of this study was to investigate risk factors affecting the course of mucosal melanoma patients followed in our clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and sixty\u2010one patients with mucosal melanoma prospectively documented in the German Central Malignant Melanoma Registry (<jats:styled-content style=\"fixed-case\">CMMR<\/jats:styled-content>) were included in this study. Gender, age, localization, stage at first medical examination, tumour thickness and mutational status were documented. The American Joint Committee on Cancer (<jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content>), 7th edition was used to define tumour stage. Kaplan\u2013Meier survival curves were evaluated compared with the log\u2010rank test. Multivariate Cox proportional hazard models were used to identify significant independent prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the localization, patients were categorized in 44.7% oral\u2013nasal, 28.6% genital, 20.5% anorectal and 6.2% visceral. Genital mucosal melanomas had the most favourable 5\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rate (58.6%) followed by visceral (58.3%) and oral\u2013nasal (39.3%). Anorectal melanomas had the worst <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> time (median: 21\u00a0\u00b1\u00a04.8\u00a0months) and 5\u2010year survival rate (22.7%). Patients &lt;60\u00a0years had a better survival than the older group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.013). Tumour stage at the time of the first medical examination was also a significant factor for survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Gender and mutational status were found to have no effect on survival. Age (&lt;60\u00a0years vs. \u226560\u00a0years; <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a02.1) and stage at first medical examination (Stage I vs. Stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>;<jats:styled-content style=\"fixed-case\"> HR<\/jats:styled-content>\u00a0=\u00a08.2) are shown to be significant independent prognostic factors on multivariate Cox regression analysis, but not localization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, we observed that older age and advanced stage have significant negative effects on the survival of mucosal melanoma. Thus, the <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content> staging system is applicable for mucosal melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.16306","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T14:52:10Z","timestamp":1582210330000},"page":"2021-2025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Prognostic factors in 161 patients with mucosal melanoma: a study of German Central Malignant Melanoma Registry"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9870-9733","authenticated-orcid":false,"given":"E.","family":"Sarac","sequence":"first","affiliation":[{"name":"Center for Dermatooncology Department of Dermatology Eberhard Karls University of Tuebingen Tuebingen Germany"},{"name":"Department of Dermatology Koc University Hospital Istanbul 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