{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:55:14Z","timestamp":1790636114920,"version":"4.1.0"},"reference-count":101,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Demodex<\/jats:italic>\n                    mites are microscopic arachnids found in the normal skin of many mammals. In humans, it is well established that\n                    <jats:italic>Demodex<\/jats:italic>\n                    mite density is higher in patients with the skin condition rosacea, and treatment with acaricidal agents is effective in resolving symptoms. However, pathophysiology of rosacea is complex and multifactorial. In dogs, demodicosis is a significant veterinary issue, particularly the generalized form of the disease which can be fatal if untreated. In each species, clinical and molecular studies have shown that the host\u2019s immunological interactions with\n                    <jats:italic>Demodex<\/jats:italic>\n                    mites are an important, but not fully understood, aspect of how\n                    <jats:italic>Demodex<\/jats:italic>\n                    can live in the skin either as a harmless commensal organism or as a pathogenic agent. This review outlines the role of\n                    <jats:italic>Demodex<\/jats:italic>\n                    mites in humans and dogs, considering morphology, prevalence, symptoms, diagnosis, histology treatment and pathogenesis.\n                  <\/jats:p>","DOI":"10.1111\/jdv.16461","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T14:05:00Z","timestamp":1586959500000},"page":"62-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["<i>Demodex<\/i>\n                    : a skin resident in man and his best friend"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9428-0052","authenticated-orcid":false,"given":"R.","family":"Foley","sequence":"first","affiliation":[{"name":"UCD Charles Institute of Dermatology University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kelly","sequence":"additional","affiliation":[{"name":"UCD Charles Institute of Dermatology University College Dublin Dublin Ireland"},{"name":"UCD School of Veterinary Medicine University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-8517","authenticated-orcid":false,"given":"S.","family":"Gatault","sequence":"additional","affiliation":[{"name":"UCD Charles Institute of Dermatology University College Dublin Dublin Ireland"},{"name":"Systems Biology Ireland University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Powell","sequence":"additional","affiliation":[{"name":"UCD Charles Institute of Dermatology University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/3278267"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2016.06.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12484"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/413719"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.21521\/mw.5697"},{"key":"e_1_2_10_7_1","first-page":"315","article-title":"Characterization of Demodex musculi infestation, associated comorbidities, and topographic distribution in a mouse strain with defective adaptive immunity","volume":"67","author":"Nashat MA","year":"2017","journal-title":"Comp Med"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1622826"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/31.4.529"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.157.10.290"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119073680"},{"key":"e_1_2_10_12_1","first-page":"381","article-title":"Bovine demodicosis: prevalence, clinico\u2010pathological and diagnostic study","volume":"4","author":"Adam A\u2010SMTaSY","year":"2014","journal-title":"J Vet Adv"},{"key":"e_1_2_10_13_1","first-page":"545","article-title":"Demodicosis: new treatment, common misdiagnosis","volume":"59","author":"Charach MG","year":"2018","journal-title":"Can Vet J"},{"key":"e_1_2_10_14_1","volume-title":"Muller and Kirk\u2019s Small Animal Dermatology","author":"Miller WH","year":"2012"},{"key":"e_1_2_10_15_1","first-page":"139","article-title":"Demodex canis: redescription and reevaluation","volume":"68","author":"Nutting WB","year":"1978","journal-title":"Cornell Vet"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200006858X"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.220.623"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/mve.12304"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01099.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106265"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13517"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.03.040"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-018-0624-3"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10493-009-9272-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00769.x"},{"key":"e_1_2_10_27_1","first-page":"1043","article-title":"Natural transmission of Demodex canis in dogs","volume":"148","author":"Greve JH","year":"1966","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.5578\/mb.66410"},{"key":"e_1_2_10_29_1","first-page":"509","article-title":"Demodex (follicular mite) infesting a boy and his pet dog","volume":"25","author":"Morsy TA","year":"1995","journal-title":"J Egypt Soc Parasitol"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.67.445"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.05.034"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2019.05.012"},{"key":"e_1_2_10_33_1","first-page":"35","article-title":"Usefulness of dermoscopy in the diagnosis and monitoring treatment of demodicidosis","volume":"7","author":"Friedman P","year":"2017","journal-title":"Dermatol Pract Concept"},{"key":"e_1_2_10_34_1","first-page":"9","article-title":"Granulomatous rosacea\u2010like demodicidosis","volume":"13","author":"Lee JY","year":"2007","journal-title":"Dermatol Online J"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510030069"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12352"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.62965"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13462"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14202"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13150"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12385"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.01026.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470752487"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00619.x"},{"key":"e_1_2_10_46_1","volume-title":"Jubb, Kennedy, and Palmer's Pathology of Domestic Animals","author":"Grant Maxie M","year":"2016"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-2472-2"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2012.02.023"},{"key":"e_1_2_10_49_1","volume-title":"BSAVA Manual of Canine and Feline Dermatology","author":"Jackson H","year":"2012"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5455\/OVJ.2013.v3.i1.p53","article-title":"Digit loss due to Demodex spp. infestation in a dog: clinical and pathological features","volume":"3","author":"Grandi F","year":"2013","journal-title":"Open Vet J"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-009-0891-y"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00755.x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1971.tb06853.x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70065-2"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04495.x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00261.x"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70137-9"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.10.058"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-4182(03)80117-5"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01739.x"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00331.x"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12121"},{"key":"e_1_2_10_63_1","first-page":"1047","article-title":"Demodex et inflammation perifolliculaire chez l\u2019homme: revue et observation de 69 biopsies","volume":"113","author":"Forton F","year":"1986","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1995.tb00035.x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589703400403"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(97)80077-1"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00566.x"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1445194"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2016.08.005"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.11.131"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.117.109413"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13093"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14084"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13801"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-018-3230-9"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-0775-8"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20165214"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00964.x"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.7.3706-3715.2004"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12658"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01173.x"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1616"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12030"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.04.007"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2015.12.006"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16540"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.03.1021"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-016-5370-1"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2014.04.002"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08028.x"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16069"},{"key":"e_1_2_10_92_1","first-page":"392","article-title":"Toll\u2010like receptor 2 is overexpressed in dogs with demodicosis, Malassezia dermatitis and cutaneous bacterial infection","volume":"24","author":"Rivas AKS\u2010GL","year":"2013","journal-title":"Vet Dermatol"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12509"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1996.tb00249.x"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.7.3983"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2012.11.012"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03255.x"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2007.05.020"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01463.x"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1603\/0022-2585-40.2.146"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-012-3067-7"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(81)90291-9"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.16461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.16461","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.16461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T14:21:01Z","timestamp":1693750861000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.16461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,15]]},"references-count":101,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/jdv.16461"],"URL":"https:\/\/doi.org\/10.1111\/jdv.16461","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,15]]},"assertion":[{"value":"2019-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}